Elemental sulfur and phenols have been added to the hydrocarbons of the piperylene fraction, oligodienes, and oligoolefins. The resulting compounds show high antiwear, antiscuffing, antioxidative, and viscous properties and can, therefore, be used as multifunctional additives.

Reactions of low-molecular-weight diene and olefin oligomers with sulfur-and oxygen-containing compounds

Colloid Chemistry of Supramolecular Systems in the Modern Landscape of Russian Science

Reaction of sulfur with 2,6-di-tert-butylphenol in dipolar aprotic solvents

Covalent and Supramolecular Conjugates of Calixarenes with Some Fluorescent Dyes of the Xanthene Series

The composition of oligoethers that are components of Laprol-373 and of products of their reaction with 2,4-toluylene diisocyanate were studied by matrix-assisted laser desorption ionization mass spectrometry (MALDI-TOF).

Composition of Laprol-373 and Products of Its Reaction with 2,4-Toluylene Diisocyanate

The overexpression and activity of carbonic anhydrase (CA, EC 4.2.1.1) isoforms CA IX and CA XII promote the accumulation of exceeding protons and acidosis in the extracellular tumor environment. Sulfonamides are effective inhibitors of most families of CAs. In this study, using scaffold-hopping, indoline-5-sulfonamide analogs 4a–u of the CA IX-selective inhibitor 3 were designed and synthesized to evaluate their biological properties. 1-Acylated indoline-5-sulfonamides demonstrated inhibitory activity against tumor-associated CA IX and XII with KI values up to 132.8 nM and 41.3 nM. Compound 4f, as one of the most potent inhibitors of CA IX and XII, exhibits hypoxic selectivity, suppressing the growth of MCF7 cells at 12.9 µM, and causes partial inhibition of hypoxia-induced CA IX expression in A431 skin cancer cells. 4e and 4f reverse chemoresistance to doxorubicin of K562/4 with overexpression of P-gp.

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Indoline-5-Sulfonamides: A Role of the Core in Inhibition of Cancer-Related Carbonic Anhydrases, Antiproliferative Activity and Circumventing of Multidrug Resistance

S. E. Solov'eva

Papers

Reaction of sulfur with 2,6-di-tert-butylphenol in dipolar aprotic solvents

Covalent and Supramolecular Conjugates of Calixarenes with Some Fluorescent Dyes of the Xanthene Series

Composition of Laprol-373 and Products of Its Reaction with 2,4-Toluylene Diisocyanate

Indoline-5-Sulfonamides: A Role of the Core in Inhibition of Cancer-Related Carbonic Anhydrases, Antiproliferative Activity and Circumventing of Multidrug Resistance