S.K. Abbas

TL;DR: Perfusion in situ of the placenta of intact or previously parathyroidectomized fetal lambs has been used to assess the ability of three mid‐molecule fragments of the humanParathyroid hormone‐related protein (PTHrP) molecule to stimulate the placental transport of calcium and magnesium.

TL;DR: Perfusion in situ of the placenta of previously thyroparathyroidectomized fetal lambs has been used to compare the ability of various forms of parathyroid hormone-related protein to stimulate placental calcium transport, and it is suggested that post-translational processing of PTHrP (1-141) may occur as an activating step in thePlacenta in vivo.

TL;DR: Results provide further evidence for both the fetal parathyroid glands and the placenta containing material resembling PTHrP which may be responsible for sustaining the activity of the placental calcium pump which maintains the fetus hypercalcaemic relative to its mother.

TL;DR: It is suggested that in the ovine fetus, parathyroid hormone promotes the active transport of calcium from mother to fetus, so that in its absence the fetus must obtain its calcium for growth by reducing its calcaemia and thereby allow net diffusion of calcium to replace the action of the placental calcium pump.

TL;DR: Results clearly show that the inhibitory action of PTH(1–34) and PTHrP(1-34) on uterine contractions depends on the integrity of the amino‐terminal region of the molecule.