S
S. M. Hech
Publications - 1
Citations - 100
S. M. Hech is an academic researcher. The author has contributed to research in topics: Topoisomerase & Camptothecin. The author has an hindex of 1, co-authored 1 publications receiving 99 citations.
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Synthesis of Water-Soluble (Aminoalkyl)camptothecin Analogues: Inhibition of Topoisomerase I and Antitumor Activity.
William D. Kingsbury,Jeffrey C. Boehm,D. R. Jakas,K. G. Holden,S. M. Hech,G. Gallagher,M. J. Caranfa,Francis L. McCabe,Leo F. Faucette,Randall K. Johnson,R. P. Hertzberg +10 more
TL;DR: 9-[(dimethylamino)methyl]-10-hydroxycamptothecin (4, SK&F 104864) for development as an antitumor agent demonstrated broad-spectrum activity in preclinical tumor models and is currently undergoing Phase I clinical trials in cancer patients.