S
S. Thumma
Researcher at University of Michigan
Publications - 1
Citations - 99
S. Thumma is an academic researcher from University of Michigan. The author has contributed to research in topics: Amyotrophic lateral sclerosis & RNA Stability. The author has an hindex of 1, co-authored 1 publications receiving 63 citations.
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Abnormal RNA stability in amyotrophic lateral sclerosis.
Elizabeth M. H. Tank,Claudia Figueroa-Romero,Lucy M. Hinder,Karan Bedi,Hilary C. Archbold,Xingli Li,Kaitlin Weskamp,Nathaniel Safren,Ximena Paez-Colasante,Crystal Pacut,S. Thumma,Michelle T. Paulsen,Kai Guo,Junguk Hur,Mats Ljungman,Eva L. Feldman,Sami J. Barmada +16 more
TL;DR: Assessment of RNA synthesis and stability in cells derived from patients with C9orf72 ALS, sporadic ALS and healthy controls suggests that TDP-43 deposition leads to targeted RNA instability in ALS and FTD, and may ultimately cause cell death by disrupting energy production and protein synthesis pathways.