Tandem Radical Reactions of Carbon Monoxide, Isonitriles, and Other Reagent Equivalents of the Geminal Radical Acceptor/Radical Precursor Synthon.

1,n-Dicarbanionic Titanium Intermediates from Monocarbanionic Organometallics and Their Application in Organic Synthesis

In recent years, radical C–C bond cleavage reactions have been increasingly understood and used to perform transformations that complement traditional ionic processes. However, to date radical C–C bond cleavage/functionalization reactions have not been the subject of a dedicated review. Herein we summarize the most recent and significant developments in the radical activation and functionalization of carbon–carbon bonds, with an emphasis on both synthetic outcomes and reaction mechanisms, and highlight how these radical C–C bond cleavage reactions enable challenging transformations.

Cleavage of carbon-carbon bonds by radical reactions.

All in one pot! Radical, radical–ionic, and radical–organometallic MCR are highly convergent processes, representing a useful pathway to molecular and structural diversity (see scheme). This concept article highlights recent developments in the field and shows the potential of the strategy for the economical elaboration of various kinds of organic substrates.

Progress in multicomponent reactions (MCRs) based on ionic and organometallic processes has recently allowed the synthesis, with high efficiency, of large collections of drug-like molecules. In contrast, MCRs based on cascade radical reactions appear to have attracted, so far, much less interest. This concept article highlights the latest progress in the field and underlines the potential of such an approach. The collected examples demonstrate that radical and radical–ionic MCRs are highly convergent processes leading to useful structural diversity.

Radical and radical-ionic multicomponent processes.

The chemistry of group 10 metalacycles

La reaction tolere la presence de divers groupes fonctionnels et peut etre appliquee a des composes avec des fonctions carbonylees et lactones

S. Toda

Papers

Regioselective double vicinal carbon-carbon bond forming reactions of electron-deficient alkenes by use of allylic stannanes and organoiodo compounds

Photoaddition of Allylic and Benzylic Groups to 1,1-Dicyanoethenes Bearing Heterocyclic Substituents by Use of Organic Stannanes.

Regioselective Photoallylation of Furyl and Thienyldicyanoethenes by Allylic Stannanes via Photoinduced Electron Transfer.

Regioselective Double Vicinal Carbon-Carbon Bond-Forming Reactions of Electron-Deficient Alkenes by Use of Allylic Stannanes and Organoiodo Compounds.