S
S. V. Vtorushin
Researcher at Siberian State Medical University
Publications - 52
Citations - 684
S. V. Vtorushin is an academic researcher from Siberian State Medical University. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 11, co-authored 32 publications receiving 533 citations. Previous affiliations of S. V. Vtorushin include Russian Academy & Russian Academy of Sciences.
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Journal ArticleDOI
Cancer invasion: patterns and mechanisms
TL;DR: The results of the own studies are presented to show the association of breast cancer progression with intratumoral morphological heterogeneity, which most likely reflects the types of cancer cell migration and results from different activities of cell adhesion molecules in tumor cells of distinct morphological structures.
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Intratumor heterogeneity: nature and biological significance.
T. S. Gerashchenko,T. S. Gerashchenko,Evgeny V. Denisov,Nikolai V. Litviakov,M. V. Zavyalova,M. V. Zavyalova,S. V. Vtorushin,S. V. Vtorushin,Matvey M. Tsyganov,V. M. Perelmuter,V. M. Perelmuter,Nadezhda V. Cherdyntseva,Nadezhda V. Cherdyntseva +12 more
TL;DR: The heterogeneity of molecular disorders in various human tumors is described and modern viewpoints of its development including genetic and non-genetic factors of heterogeneity origin and the role of cancer stem cells and clonal evolution are considered.
Journal Article
The phenomenon of multi-drug resistance in the treatment of malignant tumors.
S. V. Vtorushin,Khristenko Ky,M. V. Zavyalova,V. M. Perelmuter,Nikolai V. Litviakov,Evgeny V. Denisov,Dulesova Ay,Nadezhda V. Cherdyntseva +7 more
TL;DR: The role of activation of glutathione system enzymes and apoptosis-regulating proteins in MDR formation has been shown and Physiological functions and contribution to MDR development of ABC-transporter protein families have been described.
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Intratumoral morphological heterogeneity of breast cancer: neoadjuvant chemotherapy efficiency and multidrug resistance gene expression
Evgeny V. Denisov,N. Litviakov,M. V. Zavyalova,V. M. Perelmuter,S. V. Vtorushin,Matvey M. Tsyganov,Tatiana S. Gerashchenko,Evgeny Yu. Garbukov,Elena M. Slonimskaya,Nadezhda V. Cherdyntseva +9 more
TL;DR: The data indicate that breast tumors with alveolar structures possess resistance to NAC, which is not related to high expression of MDR genes, whereas chemoresistance of tumors with trabecular structures can depend on the expression level of ABCB1.
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Phenotypic Drift as a Cause for Intratumoral Morphological Heterogeneity of Invasive Ductal Breast Carcinoma Not Otherwise Specified
M.V. Zavyalova,Evgeny V. Denisov,L. A. Tashireva,Tatiana S. Gerashchenko,N. Litviakov,Nikolay A. Skryabin,S. V. Vtorushin,Nadezhda Telegina,Elena M. Slonimskaya,Nadezhda V. Cherdyntseva,Vladimir M. Perelmuter +10 more
TL;DR: Based on the evidence, the term “phenotypic drift” has been designated as the basis for the development of intratumoral morphological heterogeneity of IDC NOS.