S
Sabine Lohmann
Researcher at Roche Applied Science
Publications - 2
Citations - 49
Sabine Lohmann is an academic researcher from Roche Applied Science. The author has contributed to research in topics: Gene expression & Point mutation. The author has an hindex of 2, co-authored 2 publications receiving 45 citations.
Papers
More filters
Journal ArticleDOI
Inactivation of TP53 correlates with disease progression and low miR-34a expression in previously treated chronic lymphocytic leukemia patients
Annika Dufour,Giuseppe Palermo,Evelyn Zellmeier,Gudrun Mellert,Guillemette Duchateau-Nguyen,Stephanie Schneider,Tobias Benthaus,Purvi M. Kakadia,Purvi M. Kakadia,Karsten Spiekermann,Wolfgang Hiddemann,Jan Braess,Sim Truong,Nancy Patten,Lin Wu,Sabine Lohmann,David Dornan,Debraj GuhaThakurta,Ru-Fang Yeh,Galina Salogub,Philippe Solal-Celigny,Anna Dmoszynska,Tadeusz Robak,Marco Montillo,John Catalano,Christian H. Geisler,Martin Weisser,Stefan K. Bohlander,Stefan K. Bohlander +28 more
TL;DR: A complete disruption of TP53 function, either by a combination of point mutations and/or del17p, was associated with a high risk for disease progression and progression-free survival of patients with a heterozygous TP53 mutation was not significantly different from patients with an completely intact TP53 locus.
Journal ArticleDOI
Gene expression analysis in biomarker research and early drug development using function tested reverse transcription quantitative real-time PCR assays.
Sabine Lohmann,Andrea Herold,Tobias Bergauer,Anton Belousov,Gisela Betzl,Mark DeMario,Manuel Dietrich,Leopoldo Luistro,Manuela Poignée-Heger,Kathy Schostack,Mary Simcox,Heiko Walch,Xuefeng Yin,Hua Zhong,Martin Weisser +14 more
TL;DR: Workflows applicable for convenient high throughput gene expression analysis in biomarker research with cell lines and xenograft mouse models as well as formalin-fixed paraffin-embedded tissue sections from various human research and clinical tumor samples are established and may lead to advances in efforts to achieve the goal of personalized health care.