S
Sabrina Pastacaldi
Researcher at University of Florence
Publications - 12
Citations - 1278
Sabrina Pastacaldi is an academic researcher from University of Florence. The author has contributed to research in topics: Hepatic stellate cell & Monocyte. The author has an hindex of 8, co-authored 12 publications receiving 1251 citations.
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Journal ArticleDOI
Ligands of peroxisome proliferator-activated receptor γ modulate profibrogenic and proinflammatory actions in hepatic stellate cells
Fabio Marra,Eva Efsen,Roberto Giulio Romanelli,Alessandra Caligiuri,Sabrina Pastacaldi,Giacomo Batignani,Andrea Bonacchi,Roberto Caporale,Giacomo Laffi,Massimo Pinzani,Paolo Gentilini +10 more
TL;DR: Activation of PPAR-gamma modulates profibrogenic and proinflammatory actions in HSCs and may contribute to confer an activated phenotype to HSCS.
Journal Article
Increased expression of monocyte chemotactic protein-1 during active hepatic fibrogenesis: correlation with monocyte infiltration.
Fabio Marra,Raffaella DeFranco,C. Grappone,Stefano Milani,Sabrina Pastacaldi,Massimo Pinzani,Roberto Giulio Romanelli,Giacomo Laffi,Paolo Gentilini +8 more
TL;DR: Comparison of serial sections of liver biopsies from patients with various degrees of necro-inflammatory activity showed that infiltration of the portal tracts with monocytes/macrophages is directly correlated with the expression of MCP-1.
Journal ArticleDOI
Monocyte chemotactic protein‐1 as a chemoattractant for human hepatic stellate cells
Fabio Marra,Roberto Giulio Romanelli,Carlo Giannini,Paola Failli,Sabrina Pastacaldi,Maria Cristina Arrighi,Massimo Pinzani,Giacomo Laffi,Paolo Montalto,Paolo Gentilini +9 more
TL;DR: A potential direct profibrogenic action of MCP‐1 is shown via HSC chemotaxis for the first time, and this study shows that the increase in cell migration was almost completely a result ofChemotaxis rather than chemokinesis.
Journal Article
Expression of monocyte chemotactic protein-1 precedes monocyte recruitment in a rat model of acute liver injury, and is modulated by vitamin E.
Fabio Marra,Raffaella DeFranco,C. Grappone,Maurizio Parola,Stefano Milani,Gabriella Leonarduzzi,Sabrina Pastacaldi,Ulrich Wenzel,Massimo Pinzani,M. U. Dianzani,Giacomo Laffi,Paolo Gentilini +11 more
TL;DR: The existence of a direct relationship between MCP-1 expression and monocyte infiltration after acute liver injury is suggested, and that preventing the generation of oxidative stress-related molecules results in decreased expression and release of this chemokine is suggested.
Journal ArticleDOI
Agonist-specific regulation of monocyte chemoattractant protein-1 expression by cyclooxygenase metabolites in hepatic stellate cells☆
Eva Efsen,Andrea Bonacchi,Sabrina Pastacaldi,Anthony J. Valente,Ulrich Wenzel,C. Tosti-Guerra,Massimo Pinzani,Giacomo Laffi,Hanna E. Abboud,Paolo Gentilini,Fabio Marra +10 more
TL;DR: The findings indicate that cross‐talk between cytokines and a prostaglandin‐cAMP pathway differentially regulates the proinflammatory potential of HSC, contributing to the modulation of liver tissue inflammation.