Sachi Inukai

TL;DR: Novel approaches for characterizing functional binding site motifs that promise to inform the understanding of how TF binding controls gene expression and ultimately contributes to phenotype are highlighted.

TL;DR: This study suggests that sncRNAs including miRNAs contribute to lifespan regulation in C. elegans, and indicates new connections between aging, stress responses, and the small RNA world.

TL;DR: The aging-affected brain miRNAs reported here may represent novel regulatory genes that also function during aging in the human brain, in agreement with trends observed in other miRNA studies in aging tissues and organisms.

TL;DR: It is demonstrated that miR-34a exerts potent antitumorigenic effects in vitro and in vivo and suggests thatmiR- 34a replacement therapy, which is currently being tested in human clinical trials, represents a promising therapeutic strategy for TNBC.

TL;DR: In this article, a computational, structure-based approach was developed to evaluate TF variants for their impact on DNA binding activity and used universal protein-binding microarrays to assay sequence-specific DNA binding activities across 41 reference and 117 variant alleles found in individuals of diverse ancestries and families with Mendelian diseases.