V
Vikram B. Wali
Researcher at Yale University
Publications - 45
Citations - 1404
Vikram B. Wali is an academic researcher from Yale University. The author has contributed to research in topics: Cancer & Triple-negative breast cancer. The author has an hindex of 21, co-authored 45 publications receiving 1125 citations. Previous affiliations of Vikram B. Wali include Yale Cancer Center & University of Louisiana at Monroe.
Papers
More filters
Journal ArticleDOI
Immunological differences between primary and metastatic breast cancer.
Borbála Székely,Veerle Bossuyt,Xiaotong Li,Vikram B. Wali,G Patwardhan,Courtney Frederick,Andrea Silber,Tristen S. Park,Malini Harigopal,Vasiliki Pelekanou,Meiling Zhang,Qin Yan,David L. Rimm,Giampaolo Bianchini,Christos Hatzis,Lajos Pusztai +15 more
TL;DR: Metastatic breast cancers are immunologically more inert than the corresponding primary tumors but some immune-oncology targets and macrophage and angiogenesis signatures show preserved expression and suggest therapeutic combinations for clinical testing.
Journal ArticleDOI
miR-34a Silences c-SRC to Attenuate Tumor Growth in Triple-Negative Breast Cancer
Brian D. Adams,Vikram B. Wali,Christopher J. Cheng,Sachi Inukai,Carmen J. Booth,Seema Agarwal,David L. Rimm,Balázs Győrffy,Libero Santarpia,Lajos Pusztai,W. Mark Saltzman,Frank J. Slack +11 more
TL;DR: It is demonstrated that miR-34a exerts potent antitumorigenic effects in vitro and in vivo and suggests thatmiR- 34a replacement therapy, which is currently being tested in human clinical trials, represents a promising therapeutic strategy for TNBC.
Journal ArticleDOI
Synergistic Antiproliferative Effects of γ-Tocotrienol and Statin Treatment on Mammary Tumor Cells
Vikram B. Wali,Paul W. Sylvester +1 more
TL;DR: Combined low dose treatment of γ-tocotrienol with individual statins may have potential value in the treatment of breast cancer without causing myotoxicity that is associated with high dose statin treatment.
Journal ArticleDOI
Endoplasmic reticulum stress mediates γ-tocotrienol-induced apoptosis in mammary tumor cells
TL;DR: It is demonstrated that ER stress apoptotic signaling is associated with γ-tocotrienol-induced apoptosis in +SA mammary tumor cells, suggesting that a decrease in HMGCoA reductase activity is not required for ε-tocOTrienol induced apoptosis.
Journal ArticleDOI
Reliability of Whole-Exome Sequencing for Assessing Intratumor Genetic Heterogeneity.
Weiwei Shi,Charlotte K.Y. Ng,Charlotte K.Y. Ng,Charlotte K.Y. Ng,Raymond S. Lim,Tingting Jiang,Sushant Kumar,Xiaotong Li,Vikram B. Wali,Salvatore Piscuoglio,Salvatore Piscuoglio,Mark Gerstein,Anees B. Chagpar,Anees B. Chagpar,Britta Weigelt,Lajos Pusztai,Lajos Pusztai,Jorge S. Reis-Filho,Christos Hatzis,Christos Hatzis +19 more
TL;DR: Excluding mutations affecting low-mappability regions or occurring in certain mutational contexts was found to reduce artifacts, yet detection of sub-clonal mutations by WES in the absence of orthogonal validation remains unreliable.