Sadahiro Kawazoe

TL;DR: Structural requirements and the known toxicity of thiono-sulfur compounds led to the hypothesis that MMI would undergo epoxidation of the C-4,5 double bond by P450 enzymes and, after being hydrolyzed, the resulting epoxide would be then decomposed to form N-methylthiourea, a proximate toxicant.

TL;DR: Evidence for the hypothesis that the nephrotoxic thiazoles, which lack 2-substituents, would undergo microsomal epoxidation of the C-4,5 double bond and, after being hydrolyzed, the resulting epoxide would be decomposed to form thioformamide, a possibly toxic metabolite was provided.

TL;DR: The results indicate that the spin adduct is nitroxide produced by the reaction of ·OH with DMPO, the first report of ESR evidence for the in vivo generation of·OH in mammals by Cr(VI).

TL;DR: Oral administration of acidic xylooligosaccharides at a daily dose of 100 mg/kg significantly prevented the development of AD-like skin lesions and one of the mechanisms is the suppressive effect on IL-12.

TL;DR: In order to investigate nickel toxicity against the yeast Saccharomyces cerevisiae, genomic responses to nickel chloride were examined using yeast DNA microarrays and revealed that exposure to 25 mM nickel chloride for 2 hr induced changes in gene expression in S. Cerevisiae.