S
Sae Geun Park
Researcher at KAIST
Publications - 2
Citations - 704
Sae Geun Park is an academic researcher from KAIST. The author has contributed to research in topics: Metabotropic glutamate receptor 5 & NMDA receptor. The author has an hindex of 2, co-authored 2 publications receiving 624 citations.
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Journal ArticleDOI
Autistic-like social behaviour in Shank2 -mutant mice improved by restoring NMDA receptor function
Hyejung Won,Hye Ryeon Lee,Heon Yung Gee,Won Mah,Jae-Ick Kim,Jiseok Lee,Seungmin Ha,Changuk Chung,Eun Suk Jung,Yi Sul Cho,Sae Geun Park,Jungsoo Lee,Kyungmin Lee,Daesoo Kim,Yong Chul Bae,Bong-Kiun Kaang,Bong-Kiun Kaang,Min Goo Lee,Eunjoon Kim +18 more
TL;DR: It is shown that Shank2-mutant (Shank2−/−) mice carrying a mutation identical to the ASD-associated microdeletion in the human SHANK2 gene exhibit ASD-like behaviours including reduced social interaction, reduced social communication by ultrasonic vocalizations, and repetitive jumping.
Journal ArticleDOI
Social deficits in IRSp53 mutant mice improved by NMDAR and mGluR5 suppression.
Woosuk Chung,Su Yeon Choi,Eunee Lee,Haram Park,Jaeseung Kang,Hanwool Park,Yeonsoo Choi,Dong Soo Lee,Sae Geun Park,Ryunhee Kim,Yi Sul Cho,Jeonghoon Choi,Myoung Hwan Kim,Jong Won Lee,Seung Joon Lee,Issac Rhim,Min Whan Jung,Daesoo Kim,Yong Chul Bae,Eunjoon Kim +19 more
TL;DR: Treatment of IRSp53−/− mice, which display enhanced NMDA receptor (NMDAR) function in the hippocampus, with memantine, an NMDAR antagonist, or MPEP, a metabotropic glutamate receptor 5 antagonist, normalized social interaction and suggested that deviation of NMDar function in either direction leads to social deficits and that correcting the deviation has beneficial effects.