B
Bong-Kiun Kaang
Researcher at UPRRP College of Natural Sciences
Publications - 255
Citations - 11510
Bong-Kiun Kaang is an academic researcher from UPRRP College of Natural Sciences. The author has contributed to research in topics: Synaptic plasticity & Long-term potentiation. The author has an hindex of 51, co-authored 236 publications receiving 9853 citations. Previous affiliations of Bong-Kiun Kaang include Yonsei University & Seoul National University.
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Journal ArticleDOI
Autistic-like social behaviour in Shank2 -mutant mice improved by restoring NMDA receptor function
Hyejung Won,Hye Ryeon Lee,Heon Yung Gee,Won Mah,Jae-Ick Kim,Jiseok Lee,Seungmin Ha,Changuk Chung,Eun Suk Jung,Yi Sul Cho,Sae Geun Park,Jungsoo Lee,Kyungmin Lee,Daesoo Kim,Yong Chul Bae,Bong-Kiun Kaang,Bong-Kiun Kaang,Min Goo Lee,Eunjoon Kim +18 more
TL;DR: It is shown that Shank2-mutant (Shank2−/−) mice carrying a mutation identical to the ASD-associated microdeletion in the human SHANK2 gene exhibit ASD-like behaviours including reduced social interaction, reduced social communication by ultrasonic vocalizations, and repetitive jumping.
Journal ArticleDOI
Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons
Brian J. Bacskai,Binyamin Hochner,M. Mahaut-Smith,Stephen R. Adams,Bong-Kiun Kaang,Eric R. Kandel,Roger Y. Tsien +6 more
TL;DR: Cyclic adenosine monophosphate (cAMP)-dependent protein kinase, labeled with fluorescein and rhodamine on the catalytic and regulatory subunits, respectively, was injected into Aplysia sensory neurons either in culture or in intact cell clusters.
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Roles of NMDA NR2B Subtype Receptor in Prefrontal Long-Term Potentiation and Contextual Fear Memory
Ming Gao Zhao,Hiroki Toyoda,Yong-Seok Lee,Yong-Seok Lee,Long Jun Wu,Long Jun Wu,Shanelle W. Ko,Xue Han Zhang,Yongheng Jia,Fanny W.F. Shum,Hui Xu,Bao Ming Li,Bong-Kiun Kaang,Bong-Kiun Kaang,Min Zhuo,Min Zhuo +15 more
TL;DR: It is reported that the activation of the NR2B and NR2A subunits of the NMDA receptor is critical for the induction of cingulate LTP, regardless of the induction protocol.
Journal ArticleDOI
Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain
TL;DR: Increasing evidence from rodent studies that ACC activation contributes to chronic pain states is discussed and several forms of synaptic plasticity that may underlie this effect are described.
Journal ArticleDOI
Synaptic protein degradation underlies destabilization of retrieved fear memory.
Sue-Hyun Lee,Jun-Hyeok Choi,Nuribalhae Lee,Hye-Ryeon Lee,Jae-Ick Kim,Nam-Kyung Yu,Sun-Lim Choi,Seung-Hee Lee,Hyoung F. Kim,Bong-Kiun Kaang +9 more
TL;DR: It is found that postsynaptic proteins were degraded in the hippocampus by polyubiquitination after retrieval of contextual fear memory, and the infusion of proteasome inhibitor into the CA1 region immediately after retrieval prevented anisomycin-induced memory impairment, as well as the extinction of fear memory.