Showing papers by "Saeid Safiri published in 2020"

Global, regional, and national burden of neck pain in the general population, 1990-2017: systematic analysis of the Global Burden of Disease Study 2017

Abstract: Objective To use data from the Global Burden of Disease Study between 1990 and 2017 to report the rates and trends of point prevalence, annual incidence, and years lived with disability for neck pain in the general population of 195 countries. Design Systematic analysis. Data source Global Burden of Diseases, Injuries, and Risk Factors Study 2017. Main outcome measures Numbers and age standardised rates per 100 000 population of neck pain point prevalence, annual incidence, and years lived with disability were compared across regions and countries by age, sex, and sociodemographic index. Estimates were reported with uncertainty intervals. Results Globally in 2017 the age standardised rates for point prevalence of neck pain per 100 000 population was 3551.1 (95% uncertainty interval 3139.5 to 3977.9), for incidence of neck pain per 100 000 population was 806.6 (713.7 to 912.5), and for years lived with disability from neck pain per 100 000 population was 352.0 (245.6 to 493.3). These estimates did not change significantly between 1990 and 2017. The global point prevalence of neck pain in 2017 was higher in females compared with males, although this was not significant at the 0.05 level. Prevalence increased with age up to 70-74 years and then decreased. Norway (6151.2 (95% uncertainty interval 5382.3 to 6959.8)), Finland (5750.3 (5058.4 to 6518.3)), and Denmark (5316 (4674 to 6030.1)) had the three highest age standardised point prevalence estimates in 2017. The largest increases in age standardised point prevalence estimates from 1990 to 2017 were in the United Kingdom (14.6% (10.6% to 18.8%)), Sweden (10.4% (6.0% to 15.4%)), and Kuwait (2.6% (2.0% to 3.2%)). In general, positive associations, but with fluctuations, were found between age standardised years lived with disability for neck pain and sociodemographic index at the global level and for all Global Burden of Disease regions, suggesting the burden is higher at higher sociodemographic indices. Conclusions Neck pain is a serious public health problem in the general population, with the highest burden in Norway, Finland, and Denmark. Increasing population awareness about risk factors and preventive strategies for neck pain is warranted to reduce the future burden of this condition.

COVID-19 outcomes in patients with systemic autoimmune diseases treated with immunomodulatory drugs.

Abstract: We read with great interest the paper published by Gianfrancesco and colleagues in Annals of the Rheumatic Diseases in 2020.1 They examined demographic and clinical factors associated with COVID-19 hospitalisation status in people with rheumatic disease using 600 cases from 40 countries. In their multivariable model, it was found that prednisone dose ≥10 mg/day (OR: 2.05, 95% CI 1.06 to 3.96) and anti-tumour necrosis factor inhibitor use (OR: 0.40, 95% CI 0.19 to 0.81) were associated with odds of hospitalisation.1 Patients with autoimmune diseases (AD) are at an increased risk of infectious diseases due to the effects of the disease on the immune system function, much comorbidity caused by various comorbidities such as kidney and lung damage, diabetes mellitus and hypertension, as well as the chronic use of immunomodulatory drugs.2 3 Patients treated with immunomodulatory drugs are vulnerable to viral infections,3 4 and worse prognosis of COVID-19 is probable in patients with ADs5 that need to be studied. Here, we would like to share our study results that were conducted on patients with …

Asthma and metabolic syndrome: a comprehensive systematic review and meta-analysis of observational studies.

Abstract: Introduction: This study aimed to perform a meta-analysis on the prevalence of metabolic syndrome (MetS) among patients with asthma and to measure the association asthma has with MetS. Methods: The Web of Science, Medline, Scopus, Embase and Google Scholar were searched using the "Asthma", "Metabolic Syndrome", "Dysmetabolic Syndrome", "Cardiovascular Syndrome", "Insulin Resistance Syndrome", "Prevalence", "Odds Ratio", "Cross-Sectional Studies", and "Case-Control Studies" keywords. All observational studies reporting the prevalence of MetS among people with and without asthma were included in the study. In the presence of heterogeneity, random-effects models were used to pool the prevalence and odds ratios (OR), as measures of association in cross-sectional and case-control/ cohort studies, respectively. Results: The prevalence of MetS among patients with asthma (8 studies) and the OR comparing the prevalence of MetS among patients with and without asthma (5 studies) were pooled separately. The pooled prevalence of MetS among patients with asthma was found to be 25% (95% confidence interval (CI): 13%-38%). In contrast, the overall pooled OR for MetS in patients with asthma, compared to healthy controls, was 1.34 (95% CI: 0.91-1.76), which was not statistically significant. Conclusion: The prevalence of MetS was relatively high in patients with asthma. Furthermore, the odds of MetS was higher in patients with asthma, compared to healthy controls, although this difference was not statistically significant. More original studies among different populations are needed in order to more accurately examine the association between asthma and MetS, as well as the relationship asthma has with the individual components of MetS.

A comparison of nasogastric tube insertion by SORT maneuver (sniffing position, NGT orientation, contralateral rotation, and twisting movement) versus neck flexion lateral pressure in critically ill patients admitted to ICU: a prospective randomized clinical trial

Abstract: Although many techniques have been introduced to facilitate nasogastric tube (NGT) insertion using anatomic landmarks and a group of devices, there is a lack of general consensus regarding a standard method. The current study purposed to investigate if SORT maneuver (sniffing position, NGT orientation, contralateral rotation, and twisting movement) increases the success rate of NGT correct placement versus neck flexion lateral pressure (NFLP) method. A randomized controlled trial study was conducted in two university affiliated intensive care units (tertiary referral center). Three hundred and ninety-six critically ill patients older than 18 years of age were randomly divided into SORT (n = 200) and NFLP (n = 196) groups. The technique was classified as “failed” after the third unsuccessful attempt. Patient characteristics, success rate for the first attempt, time required for the successful first attempt and overall successful insertion time, various complications including kinking, coiling and bleeding and ease of insertion were noted as main outcomes measured. Ease of insertion was significantly better in the SORT group compared to the NFLP group (P < 0.001). The number of failed attempts was significantly higher in the NFLP group (7.5%) vs the SORT group (3.0%) (P = 0.046). The pattern of complications was not different between two study groups (P = 0.242). The odds of stage II (odds ratio (OR) = 49.9; 95% confidence interval (CI) 25.2 to 98.6), stage III (OR = 67.1; 95% CI 14.9 to 302.8)) and stage IV (OR = 11.8; 95% CI 3.4 to 41.2) ease of insertion were much higher in NFLP compared to SORT group, after adjusting for age and body mass index (BMI). The odds of failure was not significantly different in NFLP group compared to SORT group (OR = 2.3; 95% CI 0.85 to 6.3), after adjusting for age and BMI. SORT technique may be considered as a promising method for successful NGT insertions in critically ill patients. However, more trials are needed to confirm the results of this study. The decision must account for individual patient and clinical factors and the operator’s experience and preference. Trial registration: The study was registered at government registry of clinical trials in Iran ( http://www.IRCT.ir ) (number: IRCT20091012002582N18, 13 March 2018)

Comorbidity of metabolic syndrome components in a population-based screening program: A latent class analysis

Abstract: Background: The prevalence of metabolic syndrome (MS) is rapidly increasing in the world Thus, the aim of the present study was to identify the latent subgroups of Iranian male adults based on MS components and investigate the effect of abnormal alanine aminotransferase (ALT) and aspartate aminotransferase (AST), high total cholesterol (TC), and low-density lipoprotein (LDL) on the odds of membership in each class Methods: In the present study, we used the data of a population-based screening program conducted on 823 urban adult men aged 25 years and older in city of Qom in 2014 Abdominal obesity, fasting blood sugar (FBS), blood pressure, and serum lipid profile were measured in participants after for at least 8 hours MS was defined according to the Adults Treatment Panel III criteria Latent class analysis was used to achieve the aims of study Analyses were conducted using PROC LCA in SAS 92 software In all analysis, p value < 005 was considered statistically significant Results: There were 3 different latent classes among participants Latent class 1, non-MS, 551%; latent lass 2, at risk, 213%; and finally latent class 3, MS, with 236% of the participants Age (OR=098, 95% CI: 098-099, high LDL (OR=027, 95% CI: 013-056), high TC (OR=812, 95% CI: 440-1500), and abnormal ALT (OR=225, 95% CI 149-341) were associated with at risk class Also, only age (OR=102, 95% CI: 101-104) was associated with MS class The most prevalent components among the participants were having low HDL (340%) and high WC (339%) Conclusion: Notable percent of samples fell in "at risk" and "MS" classes, which stress the necessity of designing preventive interventions for these specific stratums of population

Associations of regular glucosamine use with all-cause and cause-specific mortality: causality assumptions need to be checked.

Abstract: We read with great interest the manuscript published by Li and colleagues that was published in the Annals of the Rheumatic Diseases in 2020.1 They evaluated the associations of regular glucosamine use with all-cause and cause-specific mortality in a large prospective cohort. This study provides valuable and interesting results but some methodological concerns should be taken into account. First, they presented the results in term of two models (model 1 and model 2), but it is not clear how the models were built. The rationale for the confounder selection …