Showing papers in "Pharmacological Research in 2020"

TL;DR: A review High-resolution CT scan can detect lung lesion before patients show clin symptoms, which plays a greater role in COVID-19 clin screening and disease severity assessment.

TL;DR: Findings indicate that LH protects against the virus attack, making its use a novel strategy for controlling the COVID-19 disease.

TL;DR: There exists a number of candidate drugs that may inhibit infection with and replication of SARS-CoV-2, and chloroquine and hydroxychloroquine, and off-label antiviral drugs, such as the nucleotide analogue remdesivir, HIV protease inhibitors lopinavir and ritonavir, broad-spectrum antiviral Drugs arbidol and favipiravir as well as antiviral phytochemicals available to date may prevent spread.

TL;DR: This review presents the physicochemical properties of all of the FDA-approved small molecule protein kinase inhibitors.

TL;DR: The expression and activity of ACE2 is summarized in various physiological and pathological conditions, and its potential implication in the susceptibility of SARS-CoV-2 infection and the progression and prognosis of COVID-19 patients is discussed in the current review.

TL;DR: Evidence is added to the notion that older age, obesity and more advanced illness are factors associated to an increased risk of death among patients hospitalized with COVID-19.

TL;DR: Wang et al. as mentioned in this paper found that Chinese medicines played the role of antivirus, anti-inflammation and immunoregulation, and target organs protection in the management of COVID-19 by multiple components acting on multiple targets at multiple pathways.

TL;DR: The current review presents latest updates on the role of exosomes in modulation of TME, approaches for targeting TME and combination of immune checkpoint inhibitors and target chemotherapeutics.

TL;DR: A growing body of evidence suggests that ferroptosis is associated with cancer and neurodegenerative diseases (Alzheimer's disease, Parkinson's disease and Huntington's disease), and the selective induction of ferroPTosis has been adopted as a potential treatment strategy in some kinds of cancer.

TL;DR: It is suggested that remdesivir can benefit patients with SARS-CoV-2 pneumonia hospitalised outside ICU where clinical outcome was better and adverse events are less frequently observed.

TL;DR: The integration of in silico and experimental results indicated that the therapeutic effects of QFPD against COVID-19 may be attributed to the anti-inflammatory effects of MXSG, which supports the rationality of the compatibility of TCM.

TL;DR: It was found that Integrated Medicine had better effects and fewer adverse drug reactions for COVID-19 and more high-quality RCTs will be needed in the future.

TL;DR: Current professional society guidelines to not discontinue ACEIs or ARBs in the setting of the CO VID-19 pandemic or COVID-19 patients are supported, as current evidence did not confirm previous concern regarding a harmful role of ACEI/ARB in COVID/ARB patients.

TL;DR: The use of Huoxiang Zhengqi dropping pills and Lianhua Qingwen granules combined with western medicine may have clinical advantages for COVID-19 patients in improving clinical symptoms, reducing utilization rate of anti-infective drugs, and improving patient prognosis, which could pave the way for the use of complementary medicine in treating this infection.

TL;DR: Examples in the pharmacokinetics field, obesity, hyperlipidaemia, diabetes, cancer, inflammatory disease conditions, etc are used to show the link between the gut microbiota and the polypharmacology of berberine.

TL;DR: Chemopreventive effects of polyphenols are mediated by several signaling pathways against skin carcinogenesis and metastasis, implying the importance ofpolyphenols to open up new horizons in development of anti-skin cancer therapeutic strategies.

TL;DR: Investigation of the anti-colitis activity and potential mechanism of oxyberberine (OBB), a novel gut microbiota metabolite of BBR, in DSS-induced colitis mice revealed that OBB effectively improved D SS-induced experimental colitis, at least partly through maintaining the colonic integrity, inhibiting inflammation response, and modulating gut microflora profile.

TL;DR: Given the fundamental role of inflammation in diseases, such as arthritis, cancer and cardiorenal disease, curcumin may have a pivotal therapeutic role through its ability to produce beneficial anti-inflammatory effects.

TL;DR: This review discusses the MQC mechanisms and how they are linked to cardiac microvascular ischemia-reperfusion (I/R) injury, and presents potential therapeutic interventions for improving MqC in cardiacmicrovascular I/R injury.

TL;DR: A different insight into a number of CQ and HCQ pharmacological effects is proposed, suggesting a potential involvement of iron homeostasis in Sars-Cov-2 infection and COVID-19 clinical course.

TL;DR: Antiplatelet therapy might be effective in improving the ventilation/perfusion ratio in Covid-19 patients with severe respiratory failure and by modulating megakaryocytes’ function and platelet adhesion.

TL;DR: Compared with conventional western medicine group, CHM group has improvements in several clinical parameters including lung CT, clinical cure rate, ranging from mild to critical cases, length of hospital stay, total score of clinical symptoms, fever reduction time, symptom score of fever, and inflammatory biomarkers.

TL;DR: The evidence presented in this review facilitates further research and clinical applications of these two herbs, and exploration of the relationship between the chemical components and disease efficacy may be the critical next step.

TL;DR: Low, regulated amounts of H2S, when therapeutically delivered by small molecule donors, improve the function of various immune cells, and protect them against dysfunction induced by various noxious stimuli (e.g. reactive oxygen species or oxidized LDL).

TL;DR: This review supports Piceatannol as a potential anticancer and chemopreventive agent and suggests that it can be effectively employed as a capable anti-cancer drug.

TL;DR: Pre-admission antithrombotic therapy, both antiplatelet and anticoagulant, does not seem to show a protective effect in severe forms of COVID-19 with ARDS at presentation and rapidly evolving toward death.

TL;DR: Light is shed on the anti-diabetic potential of flavonoids, contribution of oxidative stress, evidence of efficacy in clinical, cellular and animal studies and nano-delivery approaches to enhance their therapeutic efficacy against T2DM.

TL;DR: Probiotics + FOS intervention can modulate gut microbiota, SCFAs and serotonin in association with improved ASD symptoms, including a hyper-serotonergic state and dopamine metabolism disorder.

TL;DR: This review summarizes the epidemiological characteristics, pathogenesis, virus structure and targeting strategies of COVID-19, and focuses on the re-purposing of clinically approved drugs and Chinese herbal medicines that may be used to treat CO VID-19 and provide new ideas for the discovery of small molecular compounds with potential therapeutic effects on novel COVID -19.

TL;DR: The author recommends the FDA-approved antidiarrhea drug; nitazoxanide to be tested in combination with azithromycin for their potential activity against SARS CoV-2, soonest and recommends testing their combined administration as early during the clinical course of COVID-19 as possible.