S
Sagartirtha Sarkar
Researcher at Cleveland Clinic
Publications - 5
Citations - 366
Sagartirtha Sarkar is an academic researcher from Cleveland Clinic. The author has contributed to research in topics: Downregulation and upregulation & Muscle hypertrophy. The author has an hindex of 5, co-authored 5 publications receiving 348 citations.
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Journal ArticleDOI
Upregulation of lysyl oxidase and MMPs during cardiac remodeling in human dilated cardiomyopathy
TL;DR: An alteration of collagen, MMPs, various cytokines and particularly, LOX participates, in part, in the remodeling of the heart leading to cardiac dysfunction and HF.
Journal ArticleDOI
Influence of cytokines and growth factors in ANG II-mediated collagen upregulation by fibroblasts in rats: role of myocytes.
TL;DR: It is shown that cardiomyocytes induce secretion of active TGF-beta in the presence of ANG II and that a paracrine action of TGF -beta subsequently induces different cytokines (IL-6) in fibroblasts, thereby promoting collagen synthesis.
Journal ArticleDOI
Role of Myocytes in Myocardial Collagen Production
TL;DR: The data suggest that factors produced by myocytes are necessary for upregulation of collagen genes in vitro and demonstrate that fibroblast-myocyte cross-talk is required for Ang II–induced collagen upregulation.
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Cardiac Overexpression of Myotrophin Triggers Myocardial Hypertrophy and Heart Failure in Transgenic Mice
Sagartirtha Sarkar,Douglas W. Leaman,Sudhiranjan Gupta,Parames C. Sil,David Young,Annitta Morehead,Debabrata Mukherjee,Norman B. Ratliff,Yaping Sun,Mary E. Rayborn,Joe G. Hollyfield,Subha Sen +11 more
TL;DR: The data show that overexpression of myotrophin results in initiation of cardiac hypertrophy that progresses to heart failure, similar to changes in human heart failure.
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Myocardial Cell Death and Regeneration during Progression of Cardiac Hypertrophy to Heart Failure
Sagartirtha Sarkar,Mamta Chawla-Sarkar,David Young,Kazutoshi Nishiyama,Mary E. Rayborn,Joe G. Hollyfield,Subha Sen +6 more
TL;DR: It is demonstrated, for the first time in an animal model, that cell death and regeneration occur simultaneously in myocytes during end-stage heart failure, a phenomenon not observed at the onset of the disease process.