Said D. Figueroa

TL;DR: No2A chelator sufficiently stabilizes copper(II) radiometal under in vivo conditions, producing conjugates with very high uptake and retention in targeted GRPr in tumor-bearing mice and preclinical evaluation in patients provides some impetus for clinical evaluation in human patients.

TL;DR: Analysis of three‐dimensional coordinate landmark data indicate that the basicrania of hard/tough diet rabbits exhibit more robust middle cranial fossae and pterygoid plates, as well as altered overall morphology of the caudal Cranial fossa, suggesting that long‐term variation in masticatory forces associated with differences in dietary properties can contribute to the complex and multifactorial development of neurocranial morphology.

TL;DR: The tridentate pyrazolyl ligand framework is suggested to be an ideal candidate for the design and development of low-valent (99m)Tc-based diagnostic radiopharmaceuticals based on BBN or other targeting vectors.

TL;DR: Evaluating the pharmacokinetic profile of aliphatic hydrocarbon, aromatic, and poly(ethylene glycol) (ether) functional groups indicated that radioconjugates incorporating aromatic linking groups generally demonstrated enhanced retention in BB2r expressing tissues in comparison to either the hydrocarbon or ether linking moieties.

TL;DR: The pharmacokinetic profile justifies investigation of this bioconjugate as a potentially useful diagnostic/therapeutic agent and would serve as a good starting point for modification and optimization of similar agents to maximize tumor uptake and minimize nontarget accumulation.