Salka S. Staekenborg

TL;DR: The findings of mechanistic studies suggest that vascular disease and alterations in glucose, insulin, and amyloid metabolism underlie the pathophysiology of dementia, but which of these mechanisms are clinically relevant is unclear.

TL;DR: Medial temporal lobe atrophy and markers of cerebrovascular disease predict the development of different types of dementia in mild cognitive impairment patients.

TL;DR: Patients with small-vessel and large-vessels VaD demonstrate different profiles of symptoms, with especially more apathy in small- Vessel VaD and more agitation/agression in large-veteran VaD.

TL;DR: Investigating the relative contribution of cerebrovascular disease and MTA to cognitive impairment in patients fulfilling diagnostic criteria for VaD found that patients with higher grades of MTA or large vessel VaD had significantly worse general cognitive and executive functioning, whereas associations with small vessel disease were restricted to worse executive functioning.

TL;DR: The specific neurological signs demonstrated by patients with VaD differ according to type of imaged cerebrovascular disease, and even in people who meet restrictive VaD criteria, small vessel disease is often seen with more subtle signs, unlike large vessel disease, which is more often related to lateralized sensorimotor changes and aphasia.