Sally Kornbluth

TL;DR: It is shown that a purified membrane fraction, in the absence of cytoplasm, can promote phosphorylation of cdc2 on both Thr 14 and Tyr 15, suggesting the existence of at least two distinctly localized subpopulations of cDC2 Tyr 15-directed kinases.

TL;DR: It is shown that the addition of heparin greatly enhances the binding of radio-labeled basic FGF to the receptor, so the BEK receptor, like FLG, also requires an interaction with heparan sulfate proteoglycans to facilitate binding to its ligands.

TL;DR: This work has identified the identification of nuclear transport factors responsible for ferrying some of the CDK-cyclins in and out of the nucleus and the demonstration that phosphorylation can regulate these transport processes and the establishment of potential links between cell-cycle checkpoints and the control of CDk-cyclin subcellular localization.

TL;DR: Immunodepletion of Scythe from extracts completely prevented reaper‐induced apoptosis without affecting apoptosis triggered by activated caspases, and a truncated variant of Scythe lacking the N‐terminal domain induced apoptosis even in the absence of reaper.

TL;DR: An essential role is described for HLA-B-associated transcript 3 (Bat3)/Scythe in controlling the acetylation of p53 required for DNA damage responses and thymocytes from Bat3-deficient mice exhibit reduced induction of puma and p21, and are resistant to DNA damage-induced apoptosis in vivo.