https://science.sciencemag.org/content/sci/5/110/206.full.pdf

The american psychological association.

https://repository.upenn.edu/cgi/viewcontent.cgi?article=1004&context=appc

Conspiracy theories as barriers to controlling the spread of COVID-19 in the U.S.

It Doesn’t Take a Village to Fall for Misinformation: Social media use, discussion heterogeneity preference, worry of the virus, faith in scientists, and COVID-19-related misinformation beliefs

The emergence and spread of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) with its attendant coronavirus disease in late 2019 (COVID-19) have brought untold social and economic hardships on the global society but with severe impacts on the sub-Saharan African households. The social and economic impacts were severe given that lifestyle in Africa is largely characterised by poor infrastructure development and social amenities. This situation increased food insecurity arising from complete loss or temporary halt of means of livelihood of the continent's households. Alongside this is loss of social security with resultant psychological stress and anxieties. This notwithstanding, developed resilience and social protection support have strengthened the African households to cope and possibly recover from the negative impacts of the COVID-19 pandemic.

Global Health Crisis

Government and social trust vs. hotel response efficacy: A protection motivation perspective on hotel stay intention during the COVID-19 pandemic

The proliferation of misinformation on social media platforms is faster than the spread of Corona Virus Diseases (COVID-19) and it can generate hefty deleterious consequences on health amid a disaster like COVID-19. Drawing upon research on the stimulus-response theory (hypodermic needle theory) and the resilience theory, this study tested a conceptual framework considering general misinformation belief, conspiracy belief, and religious misinformation belief as the stimulus; and credibility evaluations as resilience strategy; and their effects on COVID-19 individual responses. Using a self-administered online survey during the COVID-19 pandemic, the study obtained 483 useable responses and after test, finds that all-inclusive, the propagation of misinformation on social media undermines the COVID-19 individual responses. Particularly, credibility evaluation of misinformation strongly predicts the COVID-19 individual responses with positive influences and religious misinformation beliefs as well as conspiracy beliefs and general misinformation beliefs come next and influence negatively. The findings and general recommendations will help the public, in general, to be cautious about misinformation, and the respective authority of a country, in particular, for initiating proper safety measures about disastrous misinformation to protect the public health from being exploited.

Effects of misinformation on COVID-19 individual responses and recommendations for resilience of disastrous consequences of misinformation

Background: Pregnancy induced hypertension (PIH) is one of the major causes of maternal and neonatal morbidity, mortality and premature birth. 99% of the maternal deaths is occurring in developing countries like Bangladesh. Almost 12% of the maternal deaths is associated with hypertensive disorders such as PIH in pregnancy. It can be prevented by proper knowledge, awareness of the disease and its complications. We investigated the knowledge, awareness of PIH and its related factors during pregnancy among the pregnant women in Tangail, Bangladesh.Methods: A descriptive cross-sectional study among 200 pregnant women in between March 2021 to June 2021 was conducted by using a questionnaire at Sheikh Hasina Medical College Hospital (SHMC) of Tangail district, Bangladesh. Factors associated with the knowledge and awareness of PIH were investigated separately using Chi square test.Results: In this study, 92.5% of the pregnant women had heard about PIH and 10.5% pregnant women had PIH. Age group 30-35, >35 and post graduate respondents were more knowledgeable and aware than others about PIH and urban respondents were highly knowledgeable and aware to PIH compare to rural respondents. The age of the respondents, area of residence, educations, occupations, socioeconomic status were found to be significantly associated with PIH knowledge and awareness.Conclusions: The study result showed that there is need to increase public knowledge and awareness about PIH. Health educational programs throughout the rural and urban areas need to be intensified to reduce PIH-related deaths among the pregnant women in Bangladesh. 

/pdf/evaluation-of-knowledge-awareness-treatment-and-prevention-3sdl20nl.pdf

Evaluation of knowledge, awareness, treatment and prevention towards pregnancy induced hypertension among the pregnant women in Bangladesh: a hospital based cross-sectional study

Human herpesvirus 6A (HHV-6A) is a ubiquitous herpesvirus implicated in Alzheimer’s disease, although its role in its pathogenesis has not been confirmed. Here, we showed that the transcription factor ATF1 restricts HHV-6A replication, mediated by IFN-β induction. Our study provides new insights into the role of ATF1 in innate viral immunity and reveals the importance of IFN-β for regulation of HHV-6A replication, which possibly impairs HHV-6A pathogenesis. ABSTRACT The stimulus-induced cAMP response element (CRE)-binding protein (CREB) family of transcription factors bind to CREs to regulate diverse cellular responses, including proliferation, survival, and differentiation. Human herpesvirus 6A (HHV-6A), which belongs to the Betaherpesvirinae subfamily, is a lymphotropic herpesvirus frequently found in patients with neuroinflammatory diseases. Previous reports implicated the importance of CREs in the HHV-6A life cycle, although the effects of the binding of transcription factors to CREs in viral replication have not been fully elucidated. In this study, we analyzed the role of the CREB family of transcription factors during HHV-6A replication. We found that HHV-6A infection enhanced phosphorylation of the CREB family members CREB1 and activating transcription factor 1 (ATF1). Knockout (KO) of CREB1 or ATF1 enhanced viral gene expression and viral replication. The increase in viral yields in supernatants from ATF1-KO cells was greater than that in supernatants from CREB1-KO cells. Transcriptome sequencing (RNA-seq) analysis showed that sensors of the innate immune system were downregulated in ATF1-KO cells, and mRNAs of beta interferon (IFN-β) and IFN-regulated genes were reduced in these cells infected with HHV-6A. IFN-β treatment of ATF1-KO cells reduced progeny viral yields significantly, suggesting that the enhancement of viral replication was caused by a reduction of IFN-β. Taken together, our results suggest that ATF1 is activated during HHV-6A infection and restricts viral replication via IFN-β induction. IMPORTANCE Human herpesvirus 6A (HHV-6A) is a ubiquitous herpesvirus implicated in Alzheimer’s disease, although its role in its pathogenesis has not been confirmed. Here, we showed that the transcription factor ATF1 restricts HHV-6A replication, mediated by IFN-β induction. Our study provides new insights into the role of ATF1 in innate viral immunity and reveals the importance of IFN-β for regulation of HHV-6A replication, which possibly impairs HHV-6A pathogenesis.

ATF1 Restricts Human Herpesvirus 6A Replication via Beta Interferon Induction

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9536871

Salma Aktar

Papers

Effects of misinformation on COVID-19 individual responses and recommendations for resilience of disastrous consequences of misinformation

Evaluation of knowledge, awareness, treatment and prevention towards pregnancy induced hypertension among the pregnant women in Bangladesh: a hospital based cross-sectional study

ATF1 Restricts Human Herpesvirus 6A Replication via Beta Interferon Induction

SARS-CoV-2 mediated dysregulation in cell signaling events drives the severity of COVID-19