S
Sam Al-Sohaily
Researcher at Garvan Institute of Medical Research
Publications - 11
Citations - 471
Sam Al-Sohaily is an academic researcher from Garvan Institute of Medical Research. The author has contributed to research in topics: Colorectal cancer & Cancer. The author has an hindex of 9, co-authored 11 publications receiving 414 citations. Previous affiliations of Sam Al-Sohaily include University of New South Wales & Sydney South West Area Health Service.
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Journal ArticleDOI
Molecular pathways in colorectal cancer
Sam Al-Sohaily,Andrew V. Biankin,Andrew V. Biankin,Andrew V. Biankin,Rupert W. Leong,Rupert W. Leong,Maija R.J. Kohonen-Corish,Maija R.J. Kohonen-Corish,Janindra Warusavitarne +8 more
TL;DR: The genetic basis of hereditary CRC and the different pathways involved in the process of colorectal carcinogenesis are discussed, with some tumors exhibiting features of multiple pathways.
Journal ArticleDOI
Loss of special AT-rich binding protein 1 expression is a marker of poor survival in lung cancer.
Christina I. Selinger,Wendy A Cooper,Wendy A Cooper,Sam Al-Sohaily,Dessislava Mladenova,Laurent Pangon,Catherine Kennedy,Brian C. McCaughan,Clare Stirzaker,Maija R.J. Kohonen-Corish,Maija R.J. Kohonen-Corish +10 more
TL;DR: This is the first study showing that SATB1 expression is lost in early preinvasive squamous lesions and that loss of SATB2 is associated with poor prognosis in lung SCC, and it is hypothesized that the SATB 1 gene is epigenetically silenced through histone modifications.
Journal ArticleDOI
Loss of special AT-rich sequence-binding protein 1 (SATB1) predicts poor survival in patients with colorectal cancer
Sam Al-Sohaily,Sam Al-Sohaily,Christopher Henderson,Christopher Henderson,Christina I. Selinger,Laurent Pangon,Eva Segelov,Maija R.J. Kohonen-Corish,Maija R.J. Kohonen-Corish,Maija R.J. Kohonen-Corish,Janindra Warusavitarne,Janindra Warusavitarne +11 more
TL;DR: This study aims to investigate the expression pattern and the prognostic value of SATB1 in colorectal cancer by studying its role as a cell type‐specific matrix attachment region binding protein.
Journal ArticleDOI
MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasm.
Laurent Pangon,Dessislava Mladenova,Lauren Watkins,Christa Van Kralingen,Nicola Currey,Sam Al-Sohaily,Patrick Lécine,Jean-Paul Borg,Maija R.J. Kohonen-Corish,Maija R.J. Kohonen-Corish +9 more
TL;DR: It is shown that the β‐cat repressor function of MCC is strongly impaired by the presence of a disease‐associated mutation, and deleted in breast cancer 1 (DBC1) is identified as a new MCC interacting partner and regulator ofβ‐cat signaling.
Journal ArticleDOI
Identification of subgroup-specific miRNA patterns by epigenetic profiling of sporadic and Lynch syndrome-associated colorectal and endometrial carcinoma
Sippy Kaur,Johanna E. Lotsari,Sam Al-Sohaily,Janindra Warusavitarne,Maija R.J. Kohonen-Corish,Maija R.J. Kohonen-Corish,Maija R.J. Kohonen-Corish,Päivi Peltomäki +7 more
TL;DR: This study identifiesmiR-345 and miR-132 as novel differentially methylated miRNAs in CRC, thereby facilitating sub-classification of CRC and links mi-129-2 methylation to early endometrial tumorigenesis.