S
Samantha L. Ginn
Researcher at Children's Medical Research Institute
Publications - 33
Citations - 2530
Samantha L. Ginn is an academic researcher from Children's Medical Research Institute. The author has contributed to research in topics: Genetic enhancement & Adeno-associated virus. The author has an hindex of 19, co-authored 31 publications receiving 2168 citations. Previous affiliations of Samantha L. Ginn include University of Sydney & Children's Hospital at Westmead.
Papers
More filters
Journal ArticleDOI
Gene therapy clinical trials worldwide to 2012 - an update
Samantha L. Ginn,Ian E. Alexander,Ian E. Alexander,Michael Edelstein,Mohammad R. Abedi,Jo Wixon +5 more
TL;DR: This database brings together global information on gene therapy clinical trials from official agency sources, published literature, conference presentations and posters kindly provided by individual investigators or trial sponsors.
Journal ArticleDOI
Gene therapy clinical trials worldwide to 2017: An update
Samantha L. Ginn,Anais K. Amaya,Ian E. Alexander,Ian E. Alexander,Michael Edelstein,Mohammad R. Abedi +5 more
TL;DR: This review presents the analysis of clinical trials that, to the best of the knowledge, have been or are being performed worldwide, and discusses key trends since the previous review, namely the use of chimeric antigen receptor T cells for the treatment of cancer and advancements in genome editing technologies.
Journal ArticleDOI
Fibroblasts Can Be Genetically Modified to Produce Excitable Cells Capable of Electrical Coupling
TL;DR: Fibroblasts can be genetically modified to produce excitable cells capable of electrical coupling, and these observations strengthen the prospect of developing gene-based strategies for repairing cardiac conduction defects.
Journal ArticleDOI
Adeno-associated virus and lentivirus vectors mediate efficient and sustained transduction of cultured mouse and human dorsal root ganglia sensory neurons
Jane Fleming,Samantha L. Ginn,Ron P. Weinberger,Toby Trahair,Jason A. Smythe,Ian E. Alexander +5 more
TL;DR: Both vectors achieved efficient and sustained transduction of human sensory neurons in dissociated cultures, thereby directly demonstrating the exciting potential of these vectors for gene therapy applications in the PNS.
Journal ArticleDOI
Identification of liver-specific enhancer-promoter activity in the 3' untranslated region of the wild-type AAV2 genome.
Grant J Logan,Allison P Dane,Claus V. Hallwirth,Christine M. Smyth,Emilie E. Wilkie,Anais K. Amaya,Erhua Zhu,Neeta Khandekar,Samantha L. Ginn,Sophia H.Y. Liao,Sharon C. Cunningham,Natsuki Sasaki,Marti Cabanes-Creus,Marti Cabanes-Creus,Patrick P.L. Tam,David W. Russell,Leszek Lisowski,Ian E. Alexander,Ian E. Alexander +18 more
TL;DR: A previously unknown liver-specific enhancer–promoter element in the wild-type AAV2 genome is described and functionally characterize that is found between the stop codon of the cap gene, which encodes proteins that form the capsid, and the right-hand inverted terminal repeat.