Samantha L. Wilson

TL;DR: It is shown that epigenetic clocks derived from cord blood or other tissues do not accurately estimate gestational age in placental samples, and placental clocks closely track fetal age during development and may have interesting applications.

TL;DR: DNA methylation alterations underlying a portion of the transcriptional development of “canonical” PE in cluster 2 and “immunological”PE in cluster 3 are established, however, a significant number of the observed methylation changes were not associated with corresponding changes in gene expression, indicating that alternate methods of gene regulation will need to be explored.

TL;DR: Despite large changes observed in EOPE, there were challenges in reproducing genome-wide DNAm hits that are discussed, and DNAm profiling may provide an independent tool to refine clinical/pathological diagnoses into subgroups with more uniform pathology.

TL;DR: Investigation of the relationship between the number of surviving children born to a woman and telomere length over 13 years in a group of 75 Kaqchikel Mayan women found women who had fewer children exhibited shorter TLs than those who had more children, contrary to LHT's prediction.

TL;DR: Somatic mosaicism is defined with a brief overview of its main mechanisms in concrete clinical examples, the impact of next‐generation sequencing technologies in its detection is discussed, and the clinical implications associated with a discovery in the clinic are expanded.