Prospective Cohort Study

Secret History: Return of the Black Death Channel 4, 7-8pm In 1348 the Black Death swept through London, killing people within days of the appearance of their first symptoms. Exactly how many died, and why, has long been a mystery. This Secret History documentary follows experts as they pick through the evidence and reveal why the plague killed on such a scale. And they ask, what might be coming next?

Medscape

Summary Background Since December, 2019, Wuhan, China, has experienced an outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Epidemiological and clinical characteristics of patients with COVID-19 have been reported but risk factors for mortality and a detailed clinical course of illness, including viral shedding, have not been well described. Methods In this retrospective, multicentre cohort study, we included all adult inpatients (≥18 years old) with laboratory-confirmed COVID-19 from Jinyintan Hospital and Wuhan Pulmonary Hospital (Wuhan, China) who had been discharged or had died by Jan 31, 2020. Demographic, clinical, treatment, and laboratory data, including serial samples for viral RNA detection, were extracted from electronic medical records and compared between survivors and non-survivors. We used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death. Findings 191 patients (135 from Jinyintan Hospital and 56 from Wuhan Pulmonary Hospital) were included in this study, of whom 137 were discharged and 54 died in hospital. 91 (48%) patients had a comorbidity, with hypertension being the most common (58 [30%] patients), followed by diabetes (36 [19%] patients) and coronary heart disease (15 [8%] patients). Multivariable regression showed increasing odds of in-hospital death associated with older age (odds ratio 1·10, 95% CI 1·03–1·17, per year increase; p=0·0043), higher Sequential Organ Failure Assessment (SOFA) score (5·65, 2·61–12·23; p Interpretation The potential risk factors of older age, high SOFA score, and d-dimer greater than 1 μg/mL could help clinicians to identify patients with poor prognosis at an early stage. Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future. Funding Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences; National Science Grant for Distinguished Young Scholars; National Key Research and Development Program of China; The Beijing Science and Technology Project; and Major Projects of National Science and Technology on New Drug Creation and Development.

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

https://www.commed.vcu.edu/Chronic_Disease/2012/cochranrvwrschbias.pdf

The Cochrane Collaboration's tool for assessing risk of bias in randomised trials

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Food, Nutrition, Physical Activity, and the Prevention of Cancer : a Global Perspective : 食物、栄養、身体活動とがんの予防 : 世界的展望(後篇)

Erratum to 'Bilateral gluteal advancement flap for treatment of recurrent sacrococcygeal pilonidal disease: A prospective cohort study' [Int. J. Surg. 29 (2016) 1-8].

Regenerative medicine in treatment of fecal incontinence: do we understand how it works?

https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20170502.13.pdf

Role of MRI Fistulography with Gadopentate Enhancement in Assessment of Complex Anal Fistulas and Improving Surgical Outcomes

Pain after surgery is a challenging and distressing problem that may delay patients0 recovery and predispose to a number of postoperative morbidities. Relieving postoperative pain is of utmost priority in order to expedite recovery and improve surgical outcomes. To this end, different methods are used to control postoperative pain, and one of the commonly used modalities is opioid prescription. Recently, a study [1] compared the pattern of opioid prescription after surgery in the USA and in the rest of the world. As the authors concluded, postoperative opioids are being prescribed at an alarmingly high rate in the USA. Knowing that more than 90% of the US patients received opioids postoperatively as compared to 5% of patients in other countries, this should draw more attention to halt the opioid epidemic. Furthermore, this article should be thoughtfully considered as an eye-opener study that may change some paradigms to address this challenging healthcare problem. It has been assumed that the origin of the current opioid crisis dates back to the early 1990s where undertreatment of pain was recognized as a significant clinical problem [2]. Most physicians presumed that patients prescribed opioids for management of pain were not vulnerable to develop opioid use disorder. This assumption was somehow correct as less than 10% of patients who receive opioids for medical reasons develop opioid use disorder. However, as the opioid prescription rates tend to increase every year and as opioids became more available, the overall prevalence of opioid use disorder has subsequently increased.

Sameh Hany Emile

Papers

Erratum to 'Bilateral gluteal advancement flap for treatment of recurrent sacrococcygeal pilonidal disease: A prospective cohort study' [Int. J. Surg. 29 (2016) 1-8].

Regenerative medicine in treatment of fecal incontinence: do we understand how it works?

Role of MRI Fistulography with Gadopentate Enhancement in Assessment of Complex Anal Fistulas and Improving Surgical Outcomes

We Asked the Experts: Reducing Opioid Prescription After Abdominal Surgery; A Place for Nerve Block and Wound Infiltration.

Axillary breast cancer with lateral orbital metastasis in a male patient.