Showing papers by "Samir Z. Zard published in 2022"
TL;DR: In this article , a double radical addition of α,α'-bisxanthyl acetone to an alkene followed by ionic or thermal cleavage of the xanthate groups and acid-catalyzed ring closure is presented.
3 citations
TL;DR: In this paper , a versatile strategy for α-substitution of enones through the formal fusion between enones and unactivated alkenes is described, which relies on the formation and use of α-xanthyl-β-hydroxy ketones, which can be considered as synthetic equivalents of the high energy and difficult to tame alkenyl radicals.
1 citations
TL;DR: In this paper , a convergent route to 1,3-dithian-2-ones based on the radical addition of xanthates to alkenes possessing a suitably located (latent) leaving group is described.
TL;DR: In this article , a brief review of convergent routes to various six-membered carbocyclic architectures exploiting the unique radical chemistry of xanthates is described, and three approaches are discussed.
Abstract: Convergent routes to various six-membered carbocyclic architectures exploiting the unique radical chemistry of xanthates are described in this brief review. Three approaches are discussed. The first is the modification of existing cyclohexane building blocks, namely, cyclohexanones, cyclohexenones and cyclohexenes. The second deals with the construction of six-membered carbocycles by associating the chemistry of xanthates with classical ionic reactions, especially the Robinson annulation, the Michael addition and the Horner–Wadsworth–Emmons condensation. Finally, the third route is the formation of six-membered rings by direct six-exo and, but more rarely, six-endo cyclisation modes. Many of the complex structures presented herein would be tedious to obtain by more traditional methods.
TL;DR: In this article , a convergent route to 1,3-dithiolan-2-ones based on the radical addition of xanthates to allylic acetates is described.
TL;DR: In this article , a versatile strategy to access vicinally functionalized cyclopentanones and cyclohexanones is described, which takes advantage of new reagents, α-xanthyl enones, which can be prepared from the reaction of xanthate salts with the corresponding epoxyketones under mild conditions.