Samuel L. DeLuca

TL;DR: The objective of this review is to enable researchers to use the software package Rosetta for biochemical and biomedicinal studies and provide a tutorial that illustrates a basic Rosetta protocol.

TL;DR: In this paper, the authors present a cloud security fabric that has enterprise APIs for connecting to the information technology infrastructure of an enterprise, developer APIs for enabling developers to access capabilities of the fabric and connector APIs by which the fabric may discover information about entities relevant to information security of the enterprise (such as events involving users, applications, and data of the enterprises occurring on a plurality of cloud-enabled platforms, including PaaS/IaaS platforms).

TL;DR: This paper describes a comprehensive and detailed protocol using the Rosetta modeling suite to dock small-molecule ligands into comparative models and presents a strategy for assessing model quality.

TL;DR: It is demonstrated that the Rosetta computational design algorithm captures important aspects of antibody/antigen recognition, including key positions in the VH gene encoding CDR1, CDR2, and the immunoglobulin framework that are critical contributors for polyspecificity in germline antibodies.

TL;DR: Improved initial placement of the ligand is critical for successful prediction of an accurate binding position in the ‘high-resolution’ full atom refinement step, making RosettaLigand appropriate for docking medium sized ligand libraries.