S
Samuel Martínez-Meza
Researcher at University of Chile
Publications - 4
Citations - 31
Samuel Martínez-Meza is an academic researcher from University of Chile. The author has contributed to research in topics: Phosphorylation & Chemistry. The author has an hindex of 2, co-authored 2 publications receiving 14 citations.
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Journal ArticleDOI
AT2 Receptor Mediated Activation of the Tyrosine Phosphatase PTP1B Blocks Caveolin-1 Enhanced Migration, Invasion and Metastasis of Cancer Cells.
Samuel Martínez-Meza,Jorge Díaz,Alejandra Sandoval-Bórquez,Manuel Valenzuela-Valderrama,Natalia Diaz-Valdivia,Victoria Rojas-Celis,Pamela Contreras,Ricardo Huilcaman,María Paz Ocaranza,Mario Chiong,Lisette Leyton,Sergio Lavandero,Andrew F. G. Quest,Andrew F. G. Quest +13 more
TL;DR: AT2R activation reduces migration, invasion, and metastasis of cancer cells by PTP1B-mediatedCAV1 dephosphorylation and inhibition of the CAV1/Rab5/Rac1 pathway, which opens up interesting, novel therapeutic opportunities to treat metastatic cancer disease.
Journal ArticleDOI
Application of Force to a Syndecan-4 Containing Complex With Thy-1-αVβ3 Integrin Accelerates Neurite Retraction.
Francesca Burgos-Bravo,Samuel Martínez-Meza,Andrew F. G. Quest,Christian A. M. Wilson,Lisette Leyton +4 more
TL;DR: Syndecan-4 controls neurite cytoskeleton contractility by modulating αVβ3 integrin mechano-receptor function, suggesting that Mechano-transduction, cell-matrix and cell-cell interactions are likely critical events in inflammation-related disease development.
Journal ArticleDOI
Mitochondrial Dysfunction and the Glycolytic Switch Induced by Caveolin-1 Phosphorylation Promote Cancer Cell Migration, Invasion, and Metastasis
Natalia Diaz-Valdivia,L Simón,Jorge Dias,Samuel Martínez-Meza,Pamela Contreras,Renato Burgos-Ravanal,Viviana I. Pérez,Balz Frei,Lisette Leyton,Andrew F. G. Quest +9 more
TL;DR: It is shown that CAV1 expression increased glycolysis rates, while mitochondrial respiration was reduced by inhibition of the mitochondrial complex IV, which promotes the Warburg effect and ROS production, thereby increasing the metastatic potential of cancer cells.
Journal ArticleDOI
Methamphetamine induces transcriptional changes in cultured HIV-infected mature monocytes that may contribute to HIV neuropathogenesis
Vanessa Chilunda,Jessica Weiselberg,Samuel Martínez-Meza,Lwidiko E. Mhamilawa,Laura Cheney,Joan W. Berman +5 more
TL;DR: Results highlight potential molecules that may be targeted for therapy to limit the effects of meth on HIV neuropathogenesis and suggest that meth increases the infiltration of mature monocytes that have a migratory phenotype into the CNS, contributing to dysregulated inflammatory responses and viral reservoir establishment and persistence.