M
Manuel Valenzuela-Valderrama
Researcher at University of Chile
Publications - 12
Citations - 102
Manuel Valenzuela-Valderrama is an academic researcher from University of Chile. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 5, co-authored 7 publications receiving 49 citations.
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Journal ArticleDOI
The Helicobacter pylori Urease Virulence Factor Is Required for the Induction of Hypoxia-Induced Factor-1α in Gastric Cells.
Manuel Valenzuela-Valderrama,Paulina Cerda-Opazo,Steffen Backert,María Fernanda González,Nicolás Carrasco-Véliz,Carla Jorquera-Cordero,Sergio Wehinger,Jimena Canales,Denisse Bravo,Andrew F. G. Quest +9 more
TL;DR: A hitherto unexpected role for the urease protein in HIF-1α induction via TLR2 activation following H. pylori infection of gastric cells is revealed.
Journal ArticleDOI
AT2 Receptor Mediated Activation of the Tyrosine Phosphatase PTP1B Blocks Caveolin-1 Enhanced Migration, Invasion and Metastasis of Cancer Cells.
Samuel Martínez-Meza,Jorge Díaz,Alejandra Sandoval-Bórquez,Manuel Valenzuela-Valderrama,Natalia Diaz-Valdivia,Victoria Rojas-Celis,Pamela Contreras,Ricardo Huilcaman,María Paz Ocaranza,Mario Chiong,Lisette Leyton,Sergio Lavandero,Andrew F. G. Quest,Andrew F. G. Quest +13 more
TL;DR: AT2R activation reduces migration, invasion, and metastasis of cancer cells by PTP1B-mediatedCAV1 dephosphorylation and inhibition of the CAV1/Rab5/Rac1 pathway, which opens up interesting, novel therapeutic opportunities to treat metastatic cancer disease.
Journal ArticleDOI
NGF-Enhanced Vasculogenic Properties of Epithelial Ovarian Cancer Cells Is Reduced by Inhibition of the COX-2/PGE2 Signaling Axis
Maritza P. Garrido,Iván Hurtado,Manuel Valenzuela-Valderrama,Renato Salvatierra,Andrea Hernández,Margarita Vega,Alberto Selman,Andrew F. G. Quest,Carmen Romero +8 more
TL;DR: It is shown here that the pro-angiogenic effect of NGF in EOC depends on theCOX-2/PGE2 signaling axis, and inhibition COX- 2/PGe2 signaling will likely be beneficial in the treatment of EOC.
Journal ArticleDOI
Caveolin-1-Mediated Tumor Suppression Is Linked to Reduced HIF1α S-Nitrosylation and Transcriptional Activity in Hypoxia.
Carlos Sanhueza,Jimena Castillo Bennett,Manuel Valenzuela-Valderrama,Pamela Contreras,Lorena Lobos-González,America Campos,Sergio Wehinger,Sergio Wehinger,Alvaro Lladser,Rolf Kiessling,Lisette Leyton,Andrew F. G. Quest +11 more
TL;DR: CAV1-dependent tumor suppression in the absence of E-cadherin is linked to reduced Hif1α transcriptional activity via diminished NOS-mediated HIF1α S-nitrosylation.
Journal ArticleDOI
NGF/TRKA Decrease miR-145-5p Levels in Epithelial Ovarian Cancer Cells.
Maritza P. Garrido,Ignacio Torres,Alba Avila,Jonás Chnaiderman,Manuel Valenzuela-Valderrama,José Aramburo,Lorena Oróstica,Eduardo Duran-Jara,Lorena Lobos-González,Carmen Romero +9 more
TL;DR: The results suggest that the tumoral effects of NGF/TRKA depend on the regulation of miR-145-5p levels in EOC cells, and that its upregulation could be used as a possible therapeutic strategy for EOC.