Sandra Hill

TL;DR: The results indicate that syntaxin binds to munc18‐1 in a closed conformation and suggest that this conformation represents an essential intermediate in exocytosis, and suggest a model whereby syntaxin undergoes a large conformational switch that mediates the transition between the syntaxin–munc 18‐1 complex and the core complex.

TL;DR: Comparison of dHAND sequences in zebrafish, Xenopus, chick, mouse and human demonstrated conservation throughout the protein and demonstrated conservation of HAND structure and expression across species.

TL;DR: It is demonstrated that human dHAND and eHAND have unique spatial patterns of expression within human cardiac chambers, which suggests a correlation between eHanded dysregulation and the evolution of a subset of cardiomyopathies.

TL;DR: Thermal injury induces priming of alveolar macrophages, resulting in significant increases in macrophage TNF-alpha production after exposure to LPS, and the majority of this effect appears to be regulated at a posttranscriptional level.

TL;DR: Analysis of the dimethyl sulfoxide solubilized paired helical filament fraction by nuclear magnetic resonance revealed it to be composed of glycolipid in a form that was distinct from similar fractions isolated from normal aged control brains.