S
Sandra Hodge
Researcher at Royal Adelaide Hospital
Publications - 162
Citations - 6276
Sandra Hodge is an academic researcher from Royal Adelaide Hospital. The author has contributed to research in topics: Cytotoxic T cell & Proinflammatory cytokine. The author has an hindex of 37, co-authored 158 publications receiving 5307 citations. Previous affiliations of Sandra Hodge include Boston Children's Hospital & University of Adelaide.
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Journal ArticleDOI
Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo-controlled trial
Peter G. Gibson,Peter G. Gibson,Ian A. Yang,John W. Upham,John W. Upham,Paul N. Reynolds,Paul N. Reynolds,Sandra Hodge,Sandra Hodge,Alan James,Alan James,Christine Jenkins,Matthew J. Peters,Guy B. Marks,Guy B. Marks,Melissa Baraket,Heather Powell,Steven L. Taylor,Lex E. X. Leong,Geraint B. Rogers,Jodie L. Simpson +20 more
TL;DR: Children and adults with persistent symptomatic asthma experience fewer asthma exacerbations and improved quality of life when treated with oral azithromycin for 48 weeks, suggesting it might be a useful add-on therapy in persistent asthma.
Journal ArticleDOI
Alveolar macrophages from subjects with chronic obstructive pulmonary disease are deficient in their ability to phagocytose apoptotic airway epithelial cells
Sandra Hodge,Sandra Hodge,Greg Hodge,Greg Hodge,Raffaele Scicchitano,Raffaele Scicchitano,Paul N. Reynolds,Paul N. Reynolds,Mark Holmes,Mark Holmes +9 more
TL;DR: The failure to resolve epithelial damage in chronic obstructive pulmonary disease may result, at least partially, from specific defects in phagocytic ability of alveolar macrophages to ingest apoptotic airway epithelial cells.
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Smoking alters alveolar macrophage recognition and phagocytic ability: implications in chronic obstructive pulmonary disease.
TL;DR: The data indicates that a smoking-related reduction in AM phagocytic ability and expression of several important recognition molecules may be at least partially normalized in those subjects with COPD who have ceased smoking.
Journal ArticleDOI
Azithromycin Improves Macrophage Phagocytic Function and Expression of Mannose Receptor in Chronic Obstructive Pulmonary Disease
Sandra Hodge,Greg Hodge,Hubertus Jersmann,Geoffrey M. Matthews,Jessica Ahern,Mark Holmes,Paul N. Reynolds +6 more
TL;DR: The findings implicate the MR in the defective phagocytic function of AMs in COPD and as a target for the azithromycin-mediated improvement in phagcytic ability.
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Increased airway epithelial and T-cell apoptosis in COPD remains despite smoking cessation
TL;DR: Airway T-lymphocytes and airway epithelial cells (AEC) show an increased likelihood of undergoing apoptosis in COPD and if this was related to smoking and continued excess apoptosis after smoking cessation may offer a new target for therapeutic interventions.