S
Sandra Muñoz-Braceras
Researcher at Spanish National Research Council
Publications - 13
Citations - 326
Sandra Muñoz-Braceras is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Autophagy & Dictyostelium discoideum. The author has an hindex of 7, co-authored 8 publications receiving 257 citations. Previous affiliations of Sandra Muñoz-Braceras include Autonomous University of Madrid.
Papers
More filters
Journal ArticleDOI
TipC and the chorea-acanthocytosis protein VPS13A regulate autophagy in Dictyostelium and human HeLa cells.
TL;DR: Downregulation of human VPS13A in HeLa cells by RNA interference confirmed the participation of the human protein in autophagy, and the expression of the TipC C-terminal coding sequence containing these 2 motifs largely complemented the mutant phenotype.
Journal ArticleDOI
Autophagy in Dictyostelium: Mechanisms, regulation and disease in a simple biomedical model
Ana Mesquita,Elena Cardenal-Muñoz,Eunice Dominguez,Sandra Muñoz-Braceras,Beatriz Nuñez-Corcuera,Ben A. Phillips,Luis C Tábara,Qiuhong Xiong,Roberto Coria,Ludwig Eichinger,Pierre Golstein,Jason S. King,Thierry Soldati,Olivier Vincent,Ricardo Escalante +14 more
TL;DR: In recent years the understanding of, and ability to investigate, autophagy in D. discoideum has evolved significantly and will surely enable and accelerate future research using this model.
Journal ArticleDOI
VPS13A is closely associated with mitochondria and is required for efficient lysosomal degradation
TL;DR: VPS13A, which is implicated in chorea-acanthocytosis, is essential for efficient lysosomal degradation, while localized in close association with mitochondria, suggesting that inter-organelle communication may be relevant in the pathogenesis of the disease.
Journal ArticleDOI
Vmp1 Regulates PtdIns3P Signaling During Autophagosome Formation in Dictyostelium discoideum
TL;DR: It is shown that Dictyostelium cells lacking Vmp1 have elevated and aberrant PtdIns3P signaling on the ER, resulting in an increased and persistent recruitment of Atg18 and other autophagic proteins, demonstrating a previously unappreciated link between abnormal autophagy signaling and macropinocytosis.
Journal ArticleDOI
Yeast and other lower eukaryotic organisms for studies of Vps13 proteins in health and disease.
Weronika Rzepnikowska,Krzysztof Flis,Sandra Muñoz-Braceras,Regina Menezes,Ricardo Escalante,Teresa Zoladek +5 more
TL;DR: The great potential of simple eukaryotes to decipher disease mechanisms in higher organisms is described and novel insights into the pathological role of Vps13 towards ChAc are highlighted.