S
Sandra R. Wolman
Researcher at New York University
Publications - 82
Citations - 4799
Sandra R. Wolman is an academic researcher from New York University. The author has contributed to research in topics: Cell culture & Population. The author has an hindex of 29, co-authored 82 publications receiving 4689 citations. Previous affiliations of Sandra R. Wolman include Memorial Sloan Kettering Cancer Center & York University.
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Isolation and Characterization of a Spontaneously Immortalized Human Breast Epithelial Cell Line, MCF-10
Herbert D. Soule,Terry M. Maloney,Sandra R. Wolman,Ward D. Peterson,Richard Brenz,Charles M. McGrath,Jose Russo,Robert J. Pauley,Richard F. Jones,Samuel C. Brooks +9 more
TL;DR: Two sublines of a breast epithelial cell culture, MCF-10, derived from human fibrocystic mammary tissue exhibit immortality after extended cultivation in low calcium concentrations, although later passages showed minimal rearrangement and near-diploidy, the immortal cells were not karyotypically normal.
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Malignant MCF10CA1 Cell Lines Derived from Premalignant Human Breast Epithelial MCF10AT Cells
Steven J. Santner,Peter J. Dawson,Larry Tait,Herbert D. Soule,James Eliason,Anwar N. Mohamed,Sandra R. Wolman,Gloria H. Heppner,Fred R. Miller +8 more
TL;DR: The derivation of fully malignant MCF10CA1 lines are reported that complete the spectrum of progression from relatively normal breast epithelial cells to breast cancer cells capable of metastasis and show differences in morphology in culture, anchorage-independent growth, karyotype, and immunocytochemistry profiles.
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Susceptibility of Fanconi's anaemia fibroblasts to chromosome damage by carcinogens
TL;DR: Experiments in which viable FA fibroblasts were exposed to a direct-acting mutagen or carcinogen for a period of 6 d, ensuring chronic exposure of the cells during one or more cell cycles, until increased cell density inhibited further cell division.
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Evidence for the clonal origin of spontaneous metastases
TL;DR: A cultured cell line of the K-1735 melanoma was x-irradiated to induce chromosome breakage and rearrangements and then implanted into the footpads of syngenic C3H mice, indicating that the metastases were clonal and that they probably originated from different progenitor cells.
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Amplification of the c-myb oncogene in a case of human acute myelogenous leukemia
Pier Giuseppe Pelicci,Luisa Lanfrancone,Michel D. Brathwaite,Sandra R. Wolman,Riccardo Dalla-Favera +4 more
TL;DR: The oncogene c-myb, which is specifically expressed and regulated in hematopoietic cells, was found to be amplified in cell lines ML-1, ML-2, and ML-3, which were separately cultured from cells of a patient with acute myelogenous leukemia (AML).