S
Sandra Sánchez-Sarasúa
Researcher at James I University
Publications - 8
Citations - 157
Sandra Sánchez-Sarasúa is an academic researcher from James I University. The author has contributed to research in topics: Neuroinflammation & Insulin receptor. The author has an hindex of 5, co-authored 7 publications receiving 86 citations.
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Journal ArticleDOI
The effect of abscisic acid chronic treatment on neuroinflammatory markers and memory in a rat model of high-fat diet induced neuroinflammation
Sandra Sánchez-Sarasúa,Salma Moustafa,Álvaro García-Avilés,María F. López-Climent,Aurelio Gómez-Cadenas,Francisco E. Olucha-Bordonau,Ana María Sánchez-Pérez +6 more
TL;DR: Results suggest that ABA might become a new therapeutic molecule improving the neuroinflammatory status and insulin resistance and rescued cognitive performance in HFD-fed rats, as expected.
Journal ArticleDOI
Can We Treat Neuroinflammation in Alzheimer's Disease?
Sandra Sánchez-Sarasúa,Iván Fernández-Pérez,Verónica Espinosa-Fernández,Ana María Sánchez-Pérez,Juan Carlos Ledesma +4 more
TL;DR: This review highlights the importance of a broad multimodal approach to treat successfully the neuroinflammation underlying AD and introduces new players underlying neuro inflammation in AD: the activity of the endocannabinoid system and the intestinal microbiota as neuroprotectors.
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Central relaxin-3 receptor (RXFP3) activation increases ERK phosphorylation in septal cholinergic neurons and impairs spatial working memory
Héctor Albert-Gascó,Álvaro García-Avilés,Salma Moustafa,Sandra Sánchez-Sarasúa,Andrew L. Gundlach,Andrew L. Gundlach,Francisco E. Olucha-Bordonau,Ana María Sánchez-Pérez +7 more
TL;DR: The medial septum/diagonal band (MS/DB) is a relay region connecting the hypothalamus and brainstem with the hippocampus, and both the MS/DB and dorsal/ventral hippocampus receive strong topographic GABA/peptidergic projections from the nucleus incertus of the pontine tegmentum.
Journal ArticleDOI
Abscisic Acid Supplementation Rescues High Fat Diet-Induced Alterations in Hippocampal Inflammation and IRSs Expression
Alberto Ribes-Navarro,Mariam Atef,Sandra Sánchez-Sarasúa,María Teresa Beltrán-Bretones,Francisco E. Olucha-Bordonau,Ana María Sánchez-Pérez +5 more
TL;DR: ABA restored HFD-induced hippocampal alterations, including IRS1 and IRS2 expression, TNFα, APP, and BDNF levels and neurogenesis, and strongly supports ABA therapeutic effects.
Journal ArticleDOI
Central relaxin-3 receptor (RXFP3) activation impairs social recognition and modulates ERK-phosphorylation in specific GABAergic amygdala neurons
Héctor Albert-Gascó,Héctor Albert-Gascó,Sandra Sánchez-Sarasúa,Sherie Ma,Sherie Ma,Sherie Ma,Cristina García-Díaz,Andrew L. Gundlach,Andrew L. Gundlach,Ana María Sánchez-Pérez,Francisco E. Olucha-Bordonau +10 more
TL;DR: Findings demonstrate that central relaxin-3/RXFP3 signalling can modulate social recognition in rats via effects within the amygdala and likely interactions with GABA and oxytocin signalling.