Showing papers by "Sanford S. Elberg published in 1960"
TL;DR: Researchers have found that the inflammatory substance may so alter mononuclear response as to reverse cytolytic susceptibility of monocytes from normal and immunized animals.
Abstract: ConclusionStudies on mononuclear cell responses to B. melitensis require that attention be paid especially to the nature of inflammatory agent itself when interpreting behavior of the mononuclear cell. The inflammatory substance may so alter mononuclear response as to reverse cytolytic susceptibility of monocytes from normal and immunized animals.
10 citations
TL;DR: A lysozyme-like material from rabbit monocytes that acts on glycine-treated brucella to cause lysis and death is described and it is proposed that intraphagocytic death involves a stepwise alteration of the wall, followed by enzymatic degradation of the mucopolysaccharide component responsible for structural integrity of the bacteria.
Abstract: SummaryA lysozyme-like material from rabbit monocytes is described. It acts on glycine-treated brucella to cause lysis and death. When parasitized monocytes containing this agent are treated with low concentrations of glycine, intracellular growth and yields of smooth Brucella melitensis, Rev Is is suppressed. The theory is proposed that intraphagocytic death involves a stepwise alteration of the wall, followed by enzymatic degradation of the mucopolysaccharide component responsible for structural integrity of the bacteria.
7 citations
TL;DR: The results of limited studies on the lyophilization and storage of a live vaccine strain of B. melitensis are described.
Abstract: The preservation of Brucella melitensis was of initerest because Elberg and Faunce (1957) had shown that a nondependent mutant derived from a streptomycindepenident strain of B. melitensis was immunogeniic wheni administered as a living vaccine. Huttoni et al. (1951) and, more recenitly, Alexander and van Drimmelen (1956), showed that lyophilization was practical for preserving the viability of the Brutcella abortus (straini 19) vaccinie. Although lyophilizationi is a geinerally accepted method for maintaining viability of bacterial cultures (Harris, 1954), the conditions for the optimal preservation of bacteria by lyophilization are not identical for all species or strains of given species. This report describes the results of limited studies on the lyophilization and storage of a live vaccine strain of B. melitensis.
5 citations