S
Sang Heui Seo
Researcher at Chungnam National University
Publications - 59
Citations - 2737
Sang Heui Seo is an academic researcher from Chungnam National University. The author has contributed to research in topics: Virus & Influenza A virus subtype H5N1. The author has an hindex of 22, co-authored 56 publications receiving 2520 citations. Previous affiliations of Sang Heui Seo include St. Jude Children's Research Hospital.
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Journal ArticleDOI
Lethal H5N1 influenza viruses escape host anti-viral cytokine responses.
TL;DR: It is shown that lethal H5N1 influenza virus, unlike other human, avian and swine influenza viruses, are resistant to the antiviral effects of interferons and tumor necrosis factor α, and the nonstructural (NS) gene of H5n1 viruses is associated with this resistance.
Journal ArticleDOI
Tumor Necrosis Factor Alpha Exerts Powerful Anti-Influenza Virus Effects in Lung Epithelial Cells
Sang Heui Seo,Robert G. Webster +1 more
TL;DR: TNF-α showed strong antiviral activity against avian, swine, and human influenza viruses, and the antiviral effect of TNF- α was greater than that of gamma or alpha interferon.
Journal ArticleDOI
Cross-Reactive, Cell-Mediated Immunity and Protection of Chickens from Lethal H5N1 Influenza Virus Infection in Hong Kong Poultry Markets
Sang Heui Seo,Robert G. Webster +1 more
TL;DR: The findings are the first to suggest that cross-reactive cellular immunity can change the outcome of avian influenza virus infection in birds in live markets and create a situation for the perpetuation of H5N1 influenza viruses.
Journal ArticleDOI
Alveolar Macrophages Are Indispensable for Controlling Influenza Viruses in Lungs of Pigs
Heui Man Kim,Youngwon Lee,Kija Lee,Hyun Soo Kim,Sung Whan Cho,Nico van Rooijen,Yi Guan,Sang Heui Seo +7 more
TL;DR: It is shown that in vivo depletion of alveolar macrophages in pigs by dichloromethylene diphosphonate (MDPCL2) treatment results in 40% mortality when pigs are infected with currently circulating human H1N1 influenza viruses, while none of the infected control pigs died.
Journal ArticleDOI
The NS1 gene of H5N1 influenza viruses circumvents the host anti-viral cytokine responses.
TL;DR: It is shown that lethal H5N1 influenza viruses, unlike other human, avian, and swine influenza virus, are resistant to the anti-viral effects of interferons and tumor necrosis factor alpha The nonstructural (NS) gene of H5n1 viruses is associated with this resistance.