E
Erich Hoffmann
Researcher at St. Jude Children's Research Hospital
Publications - 44
Citations - 11313
Erich Hoffmann is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Virus & Influenza A virus. The author has an hindex of 35, co-authored 44 publications receiving 10764 citations. Previous affiliations of Erich Hoffmann include MedImmune & World Health Organization.
Papers
More filters
Journal ArticleDOI
Universal primer set for the full-length amplification of all influenza A viruses.
TL;DR: The resultant primer set is suitable for all influenza A viruses to generate full-length cDNAs, to subtype viruses, to sequence their DNA, and to construct expression plasmids for reverse genetics systems.
Journal ArticleDOI
A DNA transfection system for generation of influenza A virus from eight plasmids
TL;DR: An eight-plasmid DNA transfection system for the rescue of infectious influenza A virus from cloned cDNA facilitates the design and recovery of both recombinant and reassortant influenza A viruses, and may also be applicable to the recovery of other RNA viruses entirely from cloning cDNA.
Journal ArticleDOI
Generation of influenza A viruses entirely from cloned cDNAs
Gabriele Neumann,Tokiko Watanabe,Hiroshi Ito,Shinji Watanabe,Hideo Goto,Peng Gao,Mark A. Hughes,Daniel R. Perez,Ruben O. Donis,Erich Hoffmann,Gerd Hobom,Yoshihiro Kawaoka +11 more
TL;DR: A new reverse-genetics system that allows one to efficiently generate influenza A viruses entirely from cloned cDNAs is described, which should be useful in viral mutagenesis studies and in the production of vaccines and gene therapy vectors.
Journal ArticleDOI
Lethal H5N1 influenza viruses escape host anti-viral cytokine responses.
TL;DR: It is shown that lethal H5N1 influenza virus, unlike other human, avian and swine influenza viruses, are resistant to the antiviral effects of interferons and tumor necrosis factor α, and the nonstructural (NS) gene of H5n1 viruses is associated with this resistance.
Journal ArticleDOI
Large-Scale Sequence Analysis of Avian Influenza Isolates
John C. Obenauer,Jackie Denson,Perdeep K. Mehta,Xiaoping Su,Suraj Mukatira,David B. Finkelstein,Xiequn Xu,Jinhua Wang,Jing Ma,Yiping Fan,Karen M. Rakestraw,Robert G. Webster,Robert G. Webster,Erich Hoffmann,Scott Krauss,Jie Zheng,Ziwei Zhang,Clayton W. Naeve,Clayton W. Naeve +18 more
TL;DR: A preliminary analysis of the first large-scale sequencing of AIVs, including 2196 AIV genes and 169 complete genomes, is reported here to identify new gene alleles, persistent genotypes, compensatory mutations, and a potential virulence determinant.