Showing papers by "Sang Jin Kim published in 2013"
TL;DR: The thinner subfoveal choroidal thickness and greater extent and density of drusen in RAP than the typical exudative AMD may suggest compromised choroid perfusion in the development of RAP.
85 citations
TL;DR: The prevalence of the BRAFV600E mutation was detected in 90 % of PTC cases, and it occurred significantly more often in female patients than in male patients, confirming the key role of this mutation in PTC tumorigenesis.
Abstract: Activating somatic mutation of the BRAF
V600E has been identified as the most common genetic event in papillary thyroid carcinoma (PTC) with a variable frequency (32–87 %) in different series by different methods. The BRAF
V600E mutation is associated with various clinicopathological parameters. The mutation is an important factor for the management of the PTC patients. The objective of this study was to detect the BRAF
V600E mutation in PTCs by peptide nucleic acid (PNA) clamp real-time PCR and to analyze the results with clinicopathological parameters. We performed genetic analysis of BRAF
V600E by PNA clamp real-time PCR in 211 PTCs in Korea, stratified by clinicopathological parameters. The BRAF
V600E mutation was detected in 90 % of PTC cases, and it occurred significantly more often in female patients than in male patients (p = 0.001). The clinicopathological parameters of age, tumor size, and disease stage were not associated with the BRAF
V600E mutation, while extrathyroid invasion (p = 0.031), lymph nodal metastasis (p = 0.002), and tumor multiplicity (p = 0.020) were. The prevalence (90 %) of the BRAF
V600E mutation in this study is the highest ever reported, confirming the key role of this mutation in PTC tumorigenesis. The BRAF
V600E mutation was associated with aggressive clinical behaviors including extrathyroid invasion, lymph nodal metastasis and tumor multifocality. The PNA clamp real-time PCR method for the BRAF
V600E mutation detection is sensitive and is applicable in a clinical setting.
40 citations
TL;DR: The observations suggest that the double-layer sign consists mainly of fibrous tissue harbored by the branching vascular network, and late geographic hyperfluorescence may originate from the staining of tissue.
36 citations
TL;DR: Intravitreal injection of human CFH resulted in the suppression of formation of new, and regression of preformed laser-induced CNV in the rat model, suggesting humanCFH may be a feasible treatment for CNV associated with age-related macular degeneration or other causes.
Abstract: Purpose To investigate the inhibitory effect of intravitreally administered human complement factor H (CFH) in a rat model of laser-induced choroidal neovascularisation (CNV). Methods Analysis of alternative pathway inhibition by human plasma-purified CFH was conducted by measuring C3 deposition on zymosan particles using rat serum. CNV was induced by laser photocoagulation on Day 0 in the eyes of Brown Norway rats. Human plasma-purified CFH (50 μg/2 μl) or phosphate buffered saline was injected intravitreally on Day 0 (prevention arm) or Day 7 (treatment arm). Seven days after injection, eyes were enucleated and retinal pigment epithelium-choroid-sclera flat mounts were prepared. Areas of CNV were determined in flat mounts and quantified using an image analysis programme. Flat mounts were also stained for membrane attack complex. Results In rat serum, human CFH inhibited activity of alternative pathway in a dose-dependent manner. On Day 3, mean membrane attack complex deposition in laser-treated retina significantly decreased in CFH-treated eyes (p<0.001). In the prevention arm, the mean CNV area in CFH-treated eyes decreased by 27.0% compared with phosphate buffered saline-treated control eyes on Day 7 (p=0.011). In the treatment arm, the mean CNV area in CFH-treated eyes decreased by 38.3% compared with control eyes on Day 14 (p=0.001). Conclusions Intravitreal injection of human CFH resulted in the suppression of formation of new, and regression of preformed laser-induced CNV in the rat model. Human CFH may be a feasible treatment for CNV associated with age-related macular degeneration or other causes.
25 citations
TL;DR: Full-thickness sclerotomy without vortex vein decompression or sclerectomy is an effective surgical option for the management of significant UES.
Abstract: To report the surgical outcome of full-thickness sclerotomy in five cases of uveal effusion syndrome (UES). Full-thickness sclerotomy without sclerectomy was performed on five eyes of four patients with UES with or without nanophthalmos. In four of the eyes, exudative retinal detachment associated with UES resolved after the sclerotomy. The subretinal fluid in one eye, which had a normal axial length, was relieved after undergoing three sclerotomy procedures. Full-thickness sclerotomy without vortex vein decompression or sclerectomy is an effective surgical option for the management of significant UES.
20 citations
TL;DR: Significant overestimation of the subfoveal choroidal thickness was noted when it was measured on a 1:1 pixel image, especially if the measurement line is not vertical, which suggests that the measurement of choroid thickness should be performed based on a1:1 micron image.
Abstract: To measure the difference in subfoveal choroidal thickness between 1:1 pixel (horizontally compressed) images and 1:1 micron images in age-related macular degeneration. This study included 122 eyes from 122 patients diagnosed with age-related macular degeneration. Choroidal thickness was measured using enhanced-depth imaging optical coherence tomography. The measurement line was drawn as a perpendicular line between Bruch’s membrane and the chorio-scleral interface. The thickness was compared between measurements based on a 1:1 pixel image and a 1:1 micron image. Eyes with a straight vertical measurement line and oblique measurement line were classified into vertical measurement group and oblique measurement group, respectively. Intra-group comparisons of subfoveal choroidal thickness measurements based on the 1:1 pixel images and the 1:1 micron images were performed for the two groups. The mean subfoveal choroidal thicknesses measured on the 1:1 pixel images and the 1:1 micron images were 232.3 ± 106.4 μm and 228.9 ± 108.1 μm, respectively (p = 0.003). In the vertical measurement group (86 eyes), the mean subfoveal choroidal thickness was 226.3 ± 109.9 μm and 225.4 ± 112.0 μm, respectively (p = 0.423). In the oblique measurement group (36 eyes), the thickness was 246.5 ± 97.3 μm and 237.5 ± 98.9 μm, respectively (p < 0.001). Significant overestimation of the subfoveal choroidal thickness was noted when it was measured on a 1:1 pixel image. This finding suggests that the measurement of choroidal thickness should be performed based on a 1:1 micron image, especially if the measurement line is not vertical.
19 citations
TL;DR: The first case of gyrate atrophy in the Korean population diagnosed by OAT gene analysis and treated with vitamin B6 dietary supplementation is described and successfully reduced without progression of chorioretinal atrophy for 15 months.
Abstract: A pair of 19-year-old female identical twins was referred to our hospital with progressive visual loss. They exhibited bilateral chorioretinal atrophy involving the midperiphery on fundoscopy and fluorescein angiography. Bilateral visual field constriction was noted on dynamic Goldmann perimetry, and a markedly impaired response was observed on both photopic and scotopic electroretinograms. Cystoid macular edema was identified in both eyes on optical coherence tomography. Plasma levels of ornithine were elevated. Based on these observations, the patients were diagnosed with gyrate atrophy of the choroid and retina. The clinical diagnosis was confirmed by mutation analysis of the ornithine-δ-aminotransferase (OAT) gene. Patients were treated with a pyridoxine supplement (300 mg/day) and an arginine-restricted diet to lower plasma levels of ornithine, which were successfully reduced without progression of chorioretinal atrophy for 15 months. Our report describes the first case of gyrate atrophy in the Korean population diagnosed by OAT gene analysis and treated with vitamin B6 dietary supplementation.
11 citations
TL;DR: A case of open surgical decompression of the CA by division of the median arcuate ligament for a 37-year-old female patient who had suffered from chronic postprandial epigastric pain and severe weight loss is reported.
Abstract: Median arcuate ligament syndrome is a rare cause of abdominal pain which results from compression of the celiac artery (CA) or rarely, the superior mesenteric artery by a ligament formed by the right and left crura of the diaphragm. We report a case of open surgical decompression of the CA by division of the median arcuate ligament for a 37-year-old female patient who had suffered from chronic postprandial epigastric pain and severe weight loss. We described clinical features, characteristic angiographic findings and details of the surgical procedure for the patient with this rare vascular problem.
10 citations
TL;DR: It is suggested that enteric-coated Maxmarvil is less harmful to gastrointestinal mucosa than alendronate, and may improve the tolerability of osteoporosis medication in clinical practice.
Abstract: Background/Aims
This study was performed to compare the mucosal findings after esophagogastroduodenoscopy in two groups before and after the use of alendronate only and following administration of the enteric-coated alendronate (5 mg) and calcitriol (0.5 µg) combined drug (Maxmarvil, Yuyu Co.).
7 citations
7 citations
TL;DR: The results suggest that, regarding conjunctival integrity, patients should be safe from intraocular contamination 15 days after 23-gauge sutureless vitrectomy and when the potential for ocular surface fluid contamination is no longer a serious concern.
Abstract: Purpose: To evaluate the healing course of conjunctival wounds in eyes undergoing 23-gauge sutureless vitrectomy and to determine when the potential for ocular surface fluid contamination is no longer a serious concern. Methods: Prospective observational case series. Thirty-four eyes from 34 patients that underwent transconjunctival 23-gauge sutureless vitrectomies were included. A total of 102 conjunctival wounds overlaying the sutureless sclerotomies from 34 eyes were evaluated prospectively by slit-lamp biomicroscopic examination using cobalt blue light with fluorescein dye staining. The configuration and size of the conjunctival wounds were measured with fluorescein dye staining postoperatively on Days 1, 4, 8, and 15. Results: Seventy-five conjunctival wounds (73.5%) had not healed completely 4 days after the operation. Eight days after surgery, the proportion of eyes with fluorescein staining at the conjunctival wound decreased to 13.7%. Fifteen days after surgery, there was no fluorescein staining at the conjunctival wound in any case. Combined cataract extraction was a factor that delayed the healing of the conjunctival wound (P = 0.036). Conclusion: The results suggest that, regarding conjunctival integrity, patients should be safe from intraocular contamination 15 days after 23-gauge sutureless vitrectomy. Concomitant cataract extraction might lengthen the conjunctival wound healing process in these eyes.
TL;DR: Proper preventive efforts should be considered while performing thyroid FNA and prompt intervention is mandatory for patients with acute hematoma after FNA.
Abstract: Fine-needle aspiration (FNA) is considered the most accurate, cost-effective and relatively safe method in the evaluation of thyroid nodules and fatal complications after thyroid FNA are uncommon. In particular, the large hematomas after FNA causing airway compromise are extremely rare complications and were reported in only a few literatures. We reported a 51-year-old woman who showed airway compromise caused by bilateral intrathyroidal and perithyroidal hematoma after FNA of thyroid. A large thyroid hematoma after FNA is a rare but possible complication and sometimes can be fatal for the patient. Proper preventive efforts should be considered while performing thyroid FNA and prompt intervention is mandatory for patients with acute hematoma after FNA.
Journal Article•
TL;DR: This research presents a novel approach to treating central giant cell granuloma using a probabilistic approach called “girdle myasthenia gravis”.
Abstract: Received May 29, 2012 Revised September 3, 2012 Accepted September 3, 2012 *Sang-jin Kim, MD Department of Neurology, Inje University Busan Paik Hospital, Inje University College of Medicine, 75 Bokji-ro, Busanjin-gu, Busan 614-735, Korea Tel: +82-51-890-6245 Fax: +82-51-895-6367 E-mail: jsk120@hanmail.net 중증근무력증은 신경근이음부의 아세틸콜린수용체에 작용 하는 항체로 인해 발생하는 자가면역질환이다. 발병 당시 안 구증상만을 보이는 경우가 50% 이상이며, 전신형으로 시작된 경우도 대부분 안구증상을 동반한다. 일반적으로 안구증상 발생 이후 점차 연수와 사지 근력저하를 보인다. 중증근무력 증에서 안구증상과 구음장애, 삼킴곤란 없이 사지만을 침범하 는 경우는 드문 형태로 팔다리이음중증근무력증(limb-girdle myasthenia gravis)이라 한다. 근위부 근력저하가 특징이고 일
31 Dec 2013
TL;DR: It is suggested that either the diagnosis or recurrence of AM can be frequently underdiagnosed because of its predominant sensory manifestations.
Abstract: Atopic myelitis (AM) is a relatively mild form of myelitis associated with allergic diathesis, and present with predominant sensory manifestations. Lhermitte’s sign has been considered as a relatively non-specific clinical sign suggesting demyelinating lesion in cervical cord. Here we report a patient with recurrent AM who presented with isolated Lhermitte’s sign, both in first and second attacks. This report suggests that either the diagnosis or recurrence of AM can be frequently underdiagnosed because of its predominant sensory manifestations.
TL;DR: This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Copyright c 2013, the Korean Thyroid Association. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 관상동맥 연축으로 진단되는 갑상선중독증 환자의 임상적 특징