Journal ArticleDOI
Thinner choroid and greater drusen extent in retinal angiomatous proliferation than in typical exudative age-related macular degeneration.
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TLDR
The thinner subfoveal choroidal thickness and greater extent and density of drusen in RAP than the typical exudative AMD may suggest compromised choroid perfusion in the development of RAP.About:
This article is published in American Journal of Ophthalmology.The article was published on 2013-04-01. It has received 85 citations till now. The article focuses on the topics: Drusen & Macular degeneration.read more
Citations
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Journal Article
Enhanced Depth Imaging Optical Coherence Tomography of the Choroid in Normal Eyes
R. Margolis,Richard F. Spaide +1 more
TL;DR: In this paper, the authors measured the macular choroid thickness in normal eyes at different points using enhanced depth imaging (EDI) optical coherence tomography (OCT) and evaluated the association of choroidal thickness and age.
Journal ArticleDOI
Ocular changes in TgF344-AD rat model of Alzheimer's disease.
YuChun Tsai,Bin Lu,Alexander V. Ljubimov,Alexander V. Ljubimov,Sergey Girman,Fred N. Ross-Cisneros,Alfredo A. Sadun,Clive N. Svendsen,Clive N. Svendsen,Robert M. Cohen,Shaomei Wang +10 more
TL;DR: In this article, a transgenic rat model was used to investigate ocular abnormalities in early stages of Alzheimer's disease, and a novel AD transgenic mouse model was analyzed to further investigate the ocular abnormality.
Journal ArticleDOI
Type 3 neovascularization: Evolution, association with pigment epithelial detachment, and treatment response as revealed by spectral domain optical coherence tomography
Aaron Nagiel,David Sarraf,Srinivas R. Sadda,Srinivas R. Sadda,Richard F. Spaide,Jesse J. Jung,Kavita V. Bhavsar,Hossein Ameri,Giuseppe Querques,K. Bailey Freund +9 more
TL;DR: In some eyes with age-related macular degeneration, the earliest sign of Type 3 neovascularization is punctate hyperreflective foci above the external limiting membrane, and the mature Type 3 lesions and associated serous pigment epithelial detachments are highly responsive to anti-vascular endothelial growth factor therapy.
Journal ArticleDOI
Reduced choriocapillaris flow in eyes with type 3 neovascularization and age-related macular degeneration.
Enrico Borrelli,Enrico Borrelli,Eric H. Souied,K. Bailey Freund,K. Bailey Freund,Giuseppe Querques,Alexandra Miere,Orly Gal-Or,Orly Gal-Or,Riccardo Sacconi,Riccardo Sacconi,Srinivas R. Sadda,David Sarraf +12 more
TL;DR: Eyes with unilateral Type 3 NV illustrated increased CC nonperfusion versus fellow nonneovascular eyes, suggesting that choroidal ischemia may play an important role in the development of Type 3NV.
Journal ArticleDOI
Subfoveal choroidal thickness as a potential predictor of visual outcome and treatment response after intravitreal ranibizumab injections for typical exudative age-related macular degeneration.
TL;DR: Subfoveal choroidal thickness may be a predictive factor for visual outcome and treatment response in typical exudative AMD after intravitreal ranibizumab injections.
References
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Journal ArticleDOI
Enhanced depth imaging spectral-domain optical coherence tomography.
TL;DR: In this paper, a method to obtain images of the choroid using conventional spectral-domain optical coherence tomography (OCT) and to evaluate choroidal thickness measurements using these images was described.
Journal ArticleDOI
A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes.
Ron Margolis,Richard F. Spaide +1 more
TL;DR: The decrease in the thickness of the choroid may play a role in the pathophysiologic features of various age-related ocular conditions and seems to vary topographically within the posterior pole.
Journal Article
Enhanced Depth Imaging Optical Coherence Tomography of the Choroid in Normal Eyes
R. Margolis,Richard F. Spaide +1 more
TL;DR: In this paper, the authors measured the macular choroid thickness in normal eyes at different points using enhanced depth imaging (EDI) optical coherence tomography (OCT) and evaluated the association of choroidal thickness and age.
Journal ArticleDOI
A simplified severity scale for age-related macular degeneration: AREDS Report No. 18.
Frederick L. Ferris,Davis,Traci E Clemons,L.–Y. Lee,Emily Y. Chew,Anne S. Lindblad,Roy C. Milton,Susan B. Bressler,Ronald Klein +8 more
TL;DR: This simplified scale provides convenient risk categories for development of advanced AMD that can be determined by clinical examination or by less demanding photographic procedures than used in the Age-Related Eye Disease Study.
Journal ArticleDOI
Retinal angiomatous proliferation in age–related macular degeneration
Lawrence A. Yannuzzi,Silvana Negrao,Tomohiro Iida,Cynthia Carvalho,Hanna Rodriguez-Coleman,Jason S. Slakter,K. Bailey Freund,John A. Sorenson,Dennis Orlock,Natalie Borodoker +9 more
TL;DR: It is suggested that angiomatous proliferation within the retina is the first manifestation of the vasogenic process in this form of neovascular ARMD, which may present in one of three vasogenic stages: IRN, SRN, or CNV.