Sara Darakhshan

TL;DR: Report on and analyze numerous properties of the active ingredient of N. sativa seeds, TQ, in the context of its therapeutic potentials for a wide range of illnesses and summarize the drug's possible mechanisms of action.

TL;DR: The findings presented in this review demonstrate the potential of tranilast for the control of a vast array of pathological situations, furthermore, it is a prescribed drug without severe side effects.

TL;DR: Findings indicate that tranilast, by synergistic effect, enhances the activity of tamoxifen and the TGF-β pathway is a target for this combination therapy, therefore, it is proposed that this combined treatment may be suitable selection in prevention of breast cancer.

TL;DR: In this paper, the effects of tamoxifen and tranilast drugs singly or in combination on proliferation of breast cancer cells and also to evaluate VEGF and MMP-9 expression and VEGf secretion levels were examined by real-time RT-PCR and ELISA assay.

TL;DR: Tranilast increases antimetastatic effect of tamoxifen and tranilast drugs as a single or in combination on invasion by two in-vitro invasion assays, and supports the importance of the CXCR4/CXCL12 interaction in breast cancer metastasis, and suggests that CX CR4 and CXCL 12 are critical targets for tamoxIFen andtranilasts in combination or alone.