Sara Morgado

TL;DR: The hypothesis that receptor–ligand crosslinking downregulates DNAM‐1 expression on NK cells from patients <65 years of age is supported and can represent an additional mechanism of tumor escape.

TL;DR: The expression of CD57, a marker of highly differentiated NK cells, is increased in the elderly; this supports the notion that a remodeling process of NK cell subsets occurs in aging with a gradual decrease in more immature CD56bright NK cells and an increase in highly differentiated CD56dim CD57+ NK cells.

TL;DR: In this paper, the authors analyzed plasma levels of pro-and anti-inflammatory cytokines in acute myeloid leukemia (AML) patients and age-matched healthy donors and found that plasma TNF-α, IL-6 and IL-10 levels were higher in AML patients from both groups of age.

TL;DR: Reduced expression of NKp46, NKp30, DNAM-1, CD244 and CD94/NKG2C activating receptors on NK cells from acute myeloid leukaemia patients is shown, which may be induced by chronic exposure to their ligands on leukaemic blasts.

TL;DR: The phenotypical characterisation of adhesion molecules and ligands for receptors involved in cell cytotoxicity on a large series of melanoma cell lines will contribute to the identification of markers useful for the development of new immunotherapy strategies.