Maria Jose Arcos

TL;DR: In this paper, the authors analyzed plasma levels of pro-and anti-inflammatory cytokines in acute myeloid leukemia (AML) patients and age-matched healthy donors and found that plasma TNF-α, IL-6 and IL-10 levels were higher in AML patients from both groups of age.

TL;DR: It can be speculated that in cancer patients the TIGIT/PVRIG pathways are upregulated and represent novel targets for checkpoint blockade immunotherapy.

TL;DR: Reduced expression of NKp46, NKp30, DNAM-1, CD244 and CD94/NKG2C activating receptors on NK cells from acute myeloid leukaemia patients is shown, which may be induced by chronic exposure to their ligands on leukaemic blasts.

TL;DR: The understanding of age-associated alterations in NK cells is therefore necessary to define adequate therapeutic strategies in older AML patients.

TL;DR: The effect of both age and cancer may act synergistically to diminish NK cell-mediated tumour immunosurveillance and the effect of immunosenescence should be considered to improve the efficiency of cancer immunotherapy.