Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal stem cells that can be isolated from many adult tissues. They can differentiate into cells of the mesodermal lineage, such as adipocytes, osteocytes and chondrocytes, as well as cells of other embryonic lineages. MSCs can interact with cells of both the innate and adaptive immune systems, leading to the modulation of several effector functions. After in vivo administration, MSCs induce peripheral tolerance and migrate to injured tissues, where they can inhibit the release of pro-inflammatory cytokines and promote the survival of damaged cells. This Review discusses the targets and mechanisms of MSC-mediated immunomodulation and the possible translation of MSCs to new therapeutic approaches.

Mesenchymal stem cells in health and disease

Immunomodulatory properties of mesenchymal stromal cells.

Cotransplantation of ex vivo expanded mesenchymal stem cells accelerates lymphocyte recovery and may reduce the risk of graft failure in haploidentical hematopoietic stem-cell transplantation.

Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-γ

https://openarchive.ki.se/xmlui/bitstream/handle/10616/40052/thesis.pdf;sequence=1

Immune modulation by mesenchymal stem cells

https://www.exphem.org/article/S0301-472X(05)00215-8/pdf

T-cell suppression mediated by mesenchymal stem cells is deficient in patients with severe aplastic anemia.

https://www.exphem.org/article/S0301-472X(06)00181-0/pdf

Sara Pozzi

Papers

T-cell suppression mediated by mesenchymal stem cells is deficient in patients with severe aplastic anemia.

Donor multipotent mesenchymal stromal cells may engraft in pediatric patients given either cord blood or bone marrow transplantation.