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Sarah C. Baumgarten
Researcher at University of Illinois at Chicago
Publications - 15
Citations - 760
Sarah C. Baumgarten is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Receptor & Cellular differentiation. The author has an hindex of 11, co-authored 13 publications receiving 605 citations.
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Journal ArticleDOI
Minireview: Inflammation: An Instigator of More Aggressive Estrogen Receptor (ER) Positive Breast Cancers
Sarah C. Baumgarten,Jonna Frasor +1 more
TL;DR: It is proposed that inflammation may promote more aggressive ER-positive tumors and that combination therapy targeting both inflammation and estrogen production or actions could benefit a significant portion of women whose ER- positive breast tumors fail to respond to endocrine therapy.
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IGF-I signaling is essential for FSH stimulation of AKT and steroidogenic genes in granulosa cells.
Ping Zhou,Sarah C. Baumgarten,Yanguang Wu,Jill Bennett,N. Winston,J. Hirshfeld-Cytron,Carlos Stocco +6 more
TL;DR: It is demonstrated, for the first time, that in human, mouse, and rat GCs, the well-known stimulatory effect of FSH on Cyp19 and AKT depends on IGF-I and on the expression and activation of the IGF-IR.
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Proinflammatory Cytokines Enhance Estrogen-dependent Expression of the Multidrug Transporter Gene ABCG2 through Estrogen Receptor and NFκB Cooperativity at Adjacent Response Elements *♦
TL;DR: Findings indicate that estrogen and inflammatory factors can modify each other's activity through modulation of transcription factor accessibility and/or occupancy at adjacent response elements and could have important implications in breast cancer.
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IGF1R signaling is necessary for FSH-induced activation of AKT and differentiation of human Cumulus granulosa cells.
TL;DR: The cumulus cell response to FSH resembles the differentiation of preantral to preovulatory granulosa cells and was abolished by the inhibition of IGF1R activity.
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IGF1R Expression in Ovarian Granulosa Cells Is Essential for Steroidogenesis, Follicle Survival, and Fertility in Female Mice.
TL;DR: In vivo findings demonstrate that IGF1R has a crucial role in GC function and, consequently, in female fertility.