Sarah E. Ernst

TL;DR: It is speculated that oral hormonal therapies for prostate cancer may alter the GI microbiota, influence clinical responses to ATT, and/or potentially modulate the antitumor effects of future therapies including immunotherapy.

TL;DR: In this article, a method of small protein identification involves adding an epitope tag to the 3' end of a short open reading frame (sORF) on the chromosome, with synthesis confirmed by immunoblot assays.

TL;DR: In this paper, the authors investigated whether bacterial prostatitis is associated with ERG+ precancerous lesions in unique cases with active bacterial infections at the time of radical prostatectomy.

TL;DR: In this paper, the authors examined the effects of Selenof on inflammatory tumorigenesis, and whether dietary selenium modified these effects, and found that the deficiency of the 15 kDa selenoprotein significantly reduced the formation of aberrant crypt foci (ACF) in a mouse model of azoxymethane (AOM)-induced colon carcinogenesis.

TL;DR: Evidence that bacterial infections initiate driver gene alterations in prostate cancer is provided, providing evidence that infection-induced ERG+ fusions are an early alteration in the carcinogenic process and PIA may serve as a direct precursor to prostate cancer.