Effect of salicylic acid and methyl jasmonate in the production of phenolic compounds in plant cell suspension cultures of Thevetia peruviana

A review on antimicrobial botanicals, phytochemicals and natural resistance modifying agents from Apocynaceae family: Possible therapeutic approaches against multidrug resistance in pathogenic microorganisms.

The family Apocynaceae is one of the largest and important families in angiosperm. Several members of this family have medicinal properties and have been in the treatment of various ailments. Most of them are consumed as food by tribal people whereas a few plants are used as source of poison. Members of family Apocynaceae are rich in alkaloids, terpenoids, steroids, flavonoids, glycosides, simple phenols, lactones, and hydrocarbons. Other compounds such as sterols, lignans, sugars, lignans, and lactones have been isolated and systematically studied. Few studies have reported antioxidant, anti-inflammatory, antimicrobial, and cytotoxic activities of crude extracts as well as single compound(s) isolated from various members of the family Apocynaceae. Holarrhena antidysenterica, Rauvolfia serpentina, Carissa carandas, and Tabernaemontana divaricata are the extensively studied plants in this family. The present review provides a detailed outlook on ethnopharmacology, phytochemistry, and biological activities of selected members of this family. Moreover, it also covers the biotechnological advances used for large-scale production of bioactive compounds of therapeutic interest along with plant tissue culture-based approaches for conservation of this medicinally valuable family.

Ethnopharmacology, phytochemistry, and biotechnological advances of family Apocynaceae: A review.

Cardenolides from the Apocynaceae family and their anticancer activity.

Investigation of the seeds of Thevetia peruviana resulted in the isolation of 15 new (2–16) and 18 known (1 and 17–33) cardiac glycosides. Eight 19-nor-cardenolides (1–8), including two rare 19-nor-10-hydroperoxycardenolides, were obtained from T. peruviana for the first time. All the structures were characterized by NMR spectroscopy and chemical derivatization. The inhibitory effects of cardiac glycosides 1–33 against three cancer cell lines (human lung cancer cells, P15; human gastric cancer cells, MGC-803; and human pancreatic cancer cells, SW1990) and one normal hepatocyte cell line, LO2, were evaluated, and a preliminary structure–activity relationship is discussed. In addition, cardiac glycosides 1, 22, 26, and 28 were evaluated for their apoptosis-inducing activities in MGC-803 cells, showing IC50 values in the range 0.02–0.53 μM.

Cardiac Glycosides from the Seeds of Thevetia peruviana.

Cardiac glycosides from Yellow Oleander (Thevetia peruviana) seeds

Sarah Kohls, Barbara M Scholz-Böttcher, Jörg Teske & Jürgen Rullkötter* Institute for Chemistry and Biology of the Marine Environment (ICBM), Carl von Ossietzky University of Oldenburg, Carl-von-Ossietzky-Str. 9-11, D-26129 Oldenburg, Germany Landeskriminalamt Niedersachsen, Kriminaltechnisches Institut, Schützenstraße 25, D-30161 Hannover, Germany Institute of Legal Medicine of the Hannover Medical School (MHH), Carl-Neuberg-Str. 1, D-30625 Hannover, Germany E-mail: j.rullkoetter@icbm.de

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Sarah Kohls

Papers

Cardiac glycosides from Yellow Oleander (Thevetia peruviana) seeds

Isolation and quantification of six cardiac glycosides from the seeds of Thevetia peruviana provide a basis for toxological survey

Method validation of a survey of thevetia cardiac glycosides in serum samples.