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Sarah M. Clinton
Researcher at University of Alabama at Birmingham
Publications - 52
Citations - 4198
Sarah M. Clinton is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Postsynaptic density & Hippocampus. The author has an hindex of 31, co-authored 48 publications receiving 3759 citations. Previous affiliations of Sarah M. Clinton include Mental Health Research Institute & Molecular and Behavioral Neuroscience Institute.
Papers
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Journal ArticleDOI
A selective role for dopamine in stimulus–reward learning
Shelly B. Flagel,Jeremy Clark,Terry E. Robinson,Leah M. Mayo,Alayna Czuj,Ingo Willuhn,Christina A. Akers,Sarah M. Clinton,Paul E. M. Phillips,Huda Akil +9 more
TL;DR: Insight is provided into the neurobiology of a form of stimulus–reward learning that confers increased susceptibility to disorders of impulse control and in individuals with a propensity for this form of learning, reward cues come to powerfully motivate and control behaviour.
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An animal model of genetic vulnerability to behavioral disinhibition and responsiveness to reward-related cues: implications for addiction.
Shelly B. Flagel,Terry E. Robinson,Jeremy Clark,Sarah M. Clinton,Stanley J. Watson,P. Seeman,Paul E. M. Phillips,Huda Akil +7 more
TL;DR: For example, this paper found that high-responder rats (bHRs) were more impulsive on a measure of impulsive action, i.e., they had difficulty withholding an action to receive a reward, indicative of behavioral disinhibition.
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Selective breeding for divergence in novelty-seeking traits: heritability and enrichment in spontaneous anxiety-related behaviors.
John D.H. Stead,Sarah M. Clinton,Charles R. Neal,Johanna Schneider,Abas Jama,Susan M. Miller,Delia M. Vazquez,Stanley J. Watson,Huda Akil +8 more
TL;DR: Responses to novelty was clearly heritable, with a >2-fold difference in behavior seen after eight generations of selection, and selected lines will enable future research on the interplay of genetic, environmental and developmental variables in controlling drug seeking behavior, stress and emotional reactivity.
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Abnormalities of the NMDA Receptor and Associated Intracellular Molecules in the Thalamus in Schizophrenia and Bipolar Disorder.
TL;DR: In the present work, increased expression of NMDA NR2B subunit transcripts, and decreased expression of all three associated postsynaptic density protein transcripts in schizophrenia are observed, and evidence of glutamatergic dysfunction in the thalamus in affective disorders, particularly in bipolar disorder is found.
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Thalamic dysfunction in schizophrenia: neurochemical, neuropathological, and in vivo imaging abnormalities
TL;DR: A review of neurochemical findings, as well as the growing body of postmortem and in vivo imaging evidence that supports the hypothesis of thalamic dysfunction in schizophrenia, suggest that the thalamus plays a critical role in processing and integrating sensory information relevant to emotional and cognitive functions in schizophrenia.