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Sarah M. Dunlap
Researcher at University of Texas at Austin
Publications - 18
Citations - 1080
Sarah M. Dunlap is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Cancer & Mammary tumor. The author has an hindex of 14, co-authored 18 publications receiving 981 citations. Previous affiliations of Sarah M. Dunlap include University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Insulin-like growth factor binding protein 2 promotes glioma development and progression
Sarah M. Dunlap,Joseph Celestino,Hua Wang,Rongcai Jiang,Rongcai Jiang,Eric C. Holland,Gregory N. Fuller,Wei Zhang +7 more
TL;DR: It is shown that IGFBP2 coexpression results in progression to a higher-grade glioma in platelet-derived growth factor β (PDGFB)-driven tumors and collaborates with K-Ras or PDGFB in the development and progression of two major types of gliomas.
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Obesity, metabolic dysregulation, and cancer: a growing concern and an inflammatory (and microenvironmental) issue.
TL;DR: In this article, the authors synthesize the evidence on key biological mechanisms underlying the obesity-cancer association, with particular emphasis on obesity-associated enhancements in growth factor signaling, inflammation, and perturbations in the tumor microenvironment.
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Leptin deficiency suppresses MMTV-Wnt-1 mammary tumor growth in obese mice and abrogates tumor initiating cell survival
Qiao Zheng,Sarah M. Dunlap,Jinling Zhu,Erinn Downs-Kelly,Jeremy N. Rich,Stephen D. Hursting,Nathan A. Berger,Ofer Reizes +7 more
TL;DR: The findings identify leptin, an adipose secreted cytokine, in promoting increased mammary tumor burden in obese mice and provide a link between this adipokine and cancer.
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Calorie restriction and cancer prevention: a mechanistic perspective
Stephen D. Hursting,Stephen D. Hursting,Sarah M. Dunlap,Nikki A. Ford,Marcie J. Hursting,Laura M. Lashinger,Laura M. Lashinger +6 more
TL;DR: Findings on the biological mechanisms underlying many of the anticancer effects of CR are synthesized, with emphasis on the impact of CR on growth factor signaling pathways, inflammation, cellular and systemic energy homeostasis pathways, vascular perturbations, and the tumor microenvironment.
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Leptin receptor maintains cancer stem-like properties in triple negative breast cancer cells
Qiao Zheng,Lauren Banaszak,Sarah L. Fracci,Diana Basali,Sarah M. Dunlap,Stephen D. Hursting,Jeremy N. Rich,Anita B Hjlemeland,Amit Vasanji,Nathan A. Berger,Justin D. Lathia,Ofer Reizes +11 more
TL;DR: The hypothesis that the leptin receptor (LEPR), expressed in mammary cancer cells, is necessary for maintaining CSC-like and metastatic properties is tested and inhibition of LEPR may be a promising therapeutic approach to inhibit NANOG and thereby neutralize CSC functions.