S
Sarah Piper
Researcher at University of Sydney
Publications - 16
Citations - 455
Sarah Piper is an academic researcher from University of Sydney. The author has contributed to research in topics: Receptor & Medicine. The author has an hindex of 7, co-authored 8 publications receiving 402 citations. Previous affiliations of Sarah Piper include University of Cambridge.
Papers
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Journal ArticleDOI
Novel Leptin-Regulated Genes Revealed by Transcriptional Profiling of the Hypothalamic Paraventricular Nucleus
Yi-Chun Loraine Tung,Marcella Ma,Sarah Piper,Anthony P. Coll,Stephen O'Rahilly,Giles S.H. Yeo +5 more
TL;DR: In this paper, the paraventricular nucleus (PVN) of the hypothalamus expressed leptin receptors and receive dense innervation from leptin receptor-expressing neurons in the arcuate nucleus.
Journal ArticleDOI
The Effects of Proopiomelanocortin Deficiency on Murine Adrenal Development and Responsiveness to Adrenocorticotropin
Anthony P. Coll,Benjamin G. Challis,Giles S.H. Yeo,Katherine Snell,Sarah Piper,David Halsall,Rosemary R. Thresher,Stephen O'Rahilly +7 more
TL;DR: The mature adrenal cortex is dependent upon proopiomelanocortin (POMC)-derived peptides for the maintenance of its size, structure, and endocrine function as mentioned in this paper.
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A comparative study of the central effects of specific proopiomelancortin (POMC)-derived melanocortin peptides on food intake and body weight in pomc null mice.
TL;DR: Although other melanocortins can reduce food intake in the short-term, only alpha-MSH can reduce the excess fat and lean mass found in Pomc-/- mice, mediated largely through an effect on food intake.
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Proopiomelanocortin-Deficient Mice Are Hypersensitive to the Adverse Metabolic Effects of Glucocorticoids
Anthony P. Coll,Benjamin G. Challis,Miguel López,Sarah Piper,Giles S.H. Yeo,Stephen O'Rahilly +5 more
TL;DR: It is concluded that glucocorticoid deficiency may afford Pomc-/- mice some protection from the full adverse consequences of melanocortin deficiency through a mechanism involving the suppression of AgRP by the hypoadrenal state.
Journal ArticleDOI
Peripheral administration of the N-terminal pro-opiomelanocortin fragment 1-28 to Pomc-/- mice reduces food intake and weight but does not affect adrenal growth or corticosterone production.
Anthony P. Coll,Martin Fassnacht,Steffen Klammer,Stephanie Hahner,Dominik M. Schulte,Sarah Piper,Y. C. Loraine Tung,Benjamin G. Challis,Yacob Weinstein,Bruno Allolio,Stephen O'Rahilly,Felix Beuschlein +11 more
TL;DR: In a mouse model which lacks all endogenous PomC peptides, treatment with synthetic 1-28 POMC alone can reduce food intake and body weight, but has no impact upon adrenal growth or steroidogenesis.