Sari Laitinen

TL;DR: It is shown through a high-resolution genome-wide single nucleotide polymorphism and copy number survey that most, if not all, metastatic prostate cancers have monoclonal origins and maintain a unique signature copy number pattern of the parent cancer cell while also accumulating a variable number of separate subclonally sustained changes.

TL;DR: Ki‐67, EZH2 and MCM7 are potential prognostic biomarkers in prostatectomy treated patients and showed independent prognostic value with relative risks in multivariate analysis.

TL;DR: The identified genetic aberrations lay the groundwork for further detailed genetic analyses of these xenografts, suggesting that the transition of the growth from androgen dependency to independence does not involve major chromosomal aberration in these two models.

TL;DR: The findings suggest that the long-term effect of androgen withdrawal on tumour growth is due to the inhibition of proliferation, suggesting that the biologic aggressiveness of a particular tumour is defined already at an early stage of disease.