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Charles M. Ewing
Researcher at Johns Hopkins University
Publications - 70
Citations - 8748
Charles M. Ewing is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Prostate cancer & Prostate. The author has an hindex of 43, co-authored 70 publications receiving 8470 citations. Previous affiliations of Charles M. Ewing include Johns Hopkins University School of Medicine & National Institutes of Natural Sciences, Japan.
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Journal ArticleDOI
Evidence for a prostate cancer susceptibility locus on the X chromosome.
Jianfeng Xu,Deborah A. Meyers,Diha Freije,Sarah D. Isaacs,Kathy E. Wiley,Deborah Nusskern,Charles M. Ewing,Eric P. Wilkens,Piroska Bujnovszky,G. Steven Bova,Patrick C. Walsh,William B. Isaacs,Johanna Schleutker,Mika P. Matikainen,Teuvo L.J. Tammela,Tapio Visakorpi,Olli Kallioniemi,Rebecca Berry,Daniel J. Schaid,Amy J. French,Shannon K. McDonnell,Jennifer J. Schroeder,Michael L. Blute,Stephen N. Thibodeau,Henrik Grönberg,Monika Emanuelsson,Jan-Erik Damber,Anders Bergh,Björn Anders Jonsson,Jeffrey R. Smith,Joan E. Bailey-Wilson,John D. Carpten,Dietrich A. Stephan,Elizabeth M. Gillanders,Isaac Amundson,Tommi Kainu,Diana Freas-Lutz,Agnes Baffoe-Bonnie,Anne Van Aucken,Raman Sood,Francis S. Collins,Michael J. Brownstein,Jeffrey M. Trent +42 more
TL;DR: Evidence for genetic locus heterogeneity was observed and genetic mapping of the locus represents an important initial step in the identification of an X-linked gene implicated in the aetiology of HPC.
Journal ArticleDOI
Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer
Wennuan Liu,Sari Laitinen,Sofia Khan,Mauno Vihinen,Jeanne Kowalski,Guoqiang Yu,Li Chen,Charles M. Ewing,Mario A. Eisenberger,Michael A. Carducci,William G. Nelson,Srinivasan Yegnasubramanian,Jun Luo,Yue Wang,Jianfeng Xu,William B. Isaacs,Tapio Visakorpi,G. Steven Bova +17 more
TL;DR: It is shown through a high-resolution genome-wide single nucleotide polymorphism and copy number survey that most, if not all, metastatic prostate cancers have monoclonal origins and maintain a unique signature copy number pattern of the parent cancer cell while also accumulating a variable number of separate subclonally sustained changes.
Journal Article
Human Prostate Cancer and Benign Prostatic Hyperplasia Molecular Dissection by Gene Expression Profiling
Jun Luo,David Duggan,Yi Chen,Jurga Sauvageot,Charles M. Ewing,Michael L. Bittner,Jeffrey M. Trent,William B. Isaacs +7 more
TL;DR: Gene expression analysis of prostate tissues should help to disclose the molecular mechanisms underlying prostate malignant growth and identify molecular markers for diagnostic, prognostic, and therapeutic use.
Journal ArticleDOI
Germline mutations in the ribonuclease L gene in families showing linkage with HPC1.
John D. Carpten,Nina N. Nupponen,Sarah D. Isaacs,Raman Sood,Christiane M. Robbins,Jianfeng Xu,Mezbah U. Faruque,Tracy Moses,Charles M. Ewing,E. Gillanders,Ping Hu,Piroska Bujnovszky,Izabela Makalowska,Agnes Baffoe-Bonnie,Agnes Baffoe-Bonnie,Dennis A. Faith,Jeffrey R. Smith,Dietrich A. Stephan,Kathy E. Wiley,Mike Brownstein,Derek Gildea,Brian Kelly,Robert B. Jenkins,Galen Hostetter,Mika P. Matikainen,Johanna Schleutker,Katherine W. Klinger,Timothy D. Connors,Ying Xiang,Zhaocheng Wang,A. M. De Marzo,Nickolas Papadopoulos,O. P. Kallioniemi,Robert D. Burk,Deborah A. Meyers,Henrik Grönberg,P. Meltzer,Robert H. Silverman,Joan E. Bailey-Wilson,Patrick C. Walsh,W. Isaacs,Jeffrey M. Trent +41 more
TL;DR: It is found that microdissected tumors with a germline mutation showed loss of heterozygosity and loss of RNase L protein, and that RNASEL activity was reduced in lymphoblasts from heterozyogous individuals compared with family members who were homozygous with respect to the wildtype allele.
Journal Article
α-methylacyl-CoA racemase: A new molecular marker for prostate cancer
Jun Luo,Shan Zha,Wesley R. Gage,Thomas A. Dunn,Jessica Hicks,Christina J. Bennett,Charles M. Ewing,Elizabeth A. Platz,Sacha Ferdinandusse,Ronald J.A. Wanders,Jeffrey M. Trent,William B. Isaacs,Angelo M. De Marzo +12 more
TL;DR: The proposed gene, α-methylacyl-CoA racemase (AMACR), is proposed as an important new marker of prostate cancer and that its use in combination with p63 staining will form the basis for an improved staining method for the identification of prostate carcinomas.